{"_buckets": {"deposit": "cd258f17-862b-456a-b90d-5eb6548ec9f9"}, "_deposit": {"created_by": 15, "id": "10262", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "10262"}, "status": "published"}, "_oai": {"id": "oai:mie-u.repo.nii.ac.jp:00010262", "sets": ["685"]}, "author_link": [], "item_10001_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2005-01-12", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1", "bibliographicPageStart": "4", "bibliographicVolumeNumber": "6", "bibliographic_titles": [{"bibliographic_title": "BMC genomics"}]}]}, "item_10001_description_19": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_10001_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background: The pregnancy-specific glycoprotein (Psg) genes encode proteins of unknown function, and are members of the carcinoembryonic antigen (Cea) gene family, which is a member of the immunoglobulin gene (Ig) superfamily. In rodents and primates, but not in artiodactyls (even-toed ungulates / hoofed mammals), there have been independent expansions of the Psg gene family, with all members expressed exclusively in placental trophoblast cells. For the mouse Psg genes, we sought to determine the genomic organisation of the locus, the expression profiles of the various family members, and the evolution of exon structure, to attempt to reconstruct the evolutionary history of this locus, and to determine whether expansion of the gene family has been driven by selection for increased gene dosage, or diversification of function.\nResults: We collated the mouse Psg gene sequences currently in the public genome and expressed-sequence tag (EST) databases and used systematic BLAST searches to generate complete sequences for all known mouse Psg genes. We identified a novel family member, Psg31, which is similar to Psg30 but, uniquely amongst mouse Psg genes, has a duplicated N1 domain. We also identified a novel splice variant of Psg16 (bCEA). We show that Psg24 and Psg30 / Psg31 have independently undergone expansion of N-domain number. By mapping BAC, YAC and cosmid clones we described two clusters of Psg genes, which we linked and oriented using fluorescent in situ hybridisation (FISH). Comparison of our Psg locus map with the public mouse genome database indicates good agreement in overall structure and further elucidates gene order. Expression levels of Psg genes in placentas of different developmental stages revealed dramatic differences in the developmental expression profile of individual family members.\nConclusion: We have combined existing information, and provide new information concerning the evolution of mouse Psg exon organization, the mouse Psg genomic locus structure, and the expression patterns of individual Psg genes. This information will facilitate functional studies of this complex gene family.", "subitem_description_type": "Abstract"}]}, "item_10001_description_6": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "page number not for citation purposes", "subitem_description_type": "Other"}]}, "item_10001_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "BioMed Central"}]}, "item_10001_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "15647114", "subitem_relation_type_select": "PMID"}}]}, "item_10001_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1186/1471-2164-6-4", "subitem_relation_type_select": "DOI"}}]}, "item_10001_relation_42": {"attribute_name": "関係URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://www.biomedcentral.com/1471-2164/6/4"}]}]}, "item_10001_source_id_11": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA12034967", "subitem_source_identifier_type": "NCID"}]}, "item_10001_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1471-2164", "subitem_source_identifier_type": "PISSN"}]}, "item_10001_subject_21": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "467", "subitem_subject_scheme": "NDC"}]}, "item_10001_text_68": {"attribute_name": "ノート", "attribute_value_mlt": [{"subitem_text_value": "出版者版電子ジャーナルあり"}]}, "item_10001_text_70": {"attribute_name": "資源タイプ(三重大)", "attribute_value_mlt": [{"subitem_text_value": "Journal Article / 学術雑誌論文"}]}, "item_10001_version_type_20": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "McLellan, Andrew S", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Fischer, Beate", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Dveksler, Gabriela", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Hori, Tomomi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Wynne, Freda", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Ball, Melanie", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Okumura, Katsuzumi", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Moore, Tom", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "Zimmermann, Wolfgang", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-02-20"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "50A7887.pdf", "filesize": [{"value": "735.0 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 735000.0, "url": {"label": "50A7887.pdf", "url": "https://mie-u.repo.nii.ac.jp/record/10262/files/50A7887.pdf"}, "version_id": "2ea6cdd3-b5e5-4c72-adae-69426d3fd925"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus", "subitem_title_language": "en"}]}, "item_type_id": "10001", "owner": "15", "path": ["685"], "permalink_uri": "http://hdl.handle.net/10076/9286", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2008-11-17"}, "publish_date": "2008-11-17", "publish_status": "0", "recid": "10262", "relation": {}, "relation_version_is_last": true, "title": ["Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus"], "weko_shared_id": -1}
Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus
http://hdl.handle.net/10076/9286
http://hdl.handle.net/10076/9286