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Introduction) A genetic analysis is developing to identify single nucleotide polymorphism (SNP) associated with lifestyle disease. Many researchers are investigating the lifestyle disease depended on one SNP. However, almost onset influence is not clear for the combination of patient\u0027s SNPs. This object of this research is the proposal of a new risk estimation method of lifestyle disease in the consideration of the relevance of SNP and biomarkers. By using this system, a physician can suggest lifestyle guidance more exactly to a subject. (2. Proposed Method) 2.1. Outline of System Figure.1 shows the flowchart of my proposed system. Figure 1 Flowchart of proposed system 2.2. Learning Process In learning process, the system generates diagnosis dictionaries from many sets of SNPs and biomarkers such as BMI, age, sex, smoking, blood pressure, cholesterol, HbA1c. The sets are normalized for each features scale. 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個人の遺伝子情報(SNP)と生活習慣病の関連性を用いた健康診断支援システム
http://hdl.handle.net/10076/13535
http://hdl.handle.net/10076/135353c62b7cd-dcc3-494f-b1ab-6f85856af697
名前 / ファイル | ライセンス | アクション |
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2012M383.pdf (2.0 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2013-11-25 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 個人の遺伝子情報(SNP)と生活習慣病の関連性を用いた健康診断支援システム | |||||
言語 | ||||||
言語 | jpn | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
資源タイプ | thesis | |||||
著者 |
森上 斐斗
× 森上 斐斗 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | (1. Introduction) A genetic analysis is developing to identify single nucleotide polymorphism (SNP) associated with lifestyle disease. Many researchers are investigating the lifestyle disease depended on one SNP. However, almost onset influence is not clear for the combination of patient's SNPs. This object of this research is the proposal of a new risk estimation method of lifestyle disease in the consideration of the relevance of SNP and biomarkers. By using this system, a physician can suggest lifestyle guidance more exactly to a subject. (2. Proposed Method) 2.1. Outline of System Figure.1 shows the flowchart of my proposed system. Figure 1 Flowchart of proposed system 2.2. Learning Process In learning process, the system generates diagnosis dictionaries from many sets of SNPs and biomarkers such as BMI, age, sex, smoking, blood pressure, cholesterol, HbA1c. The sets are normalized for each features scale. Diagnosis dictionaries are generated for each SNP types on specific disease. 2.3. Health Check Process To estimate onset risk, subject feature is compared to individual diagnosis dictionaries. Individual diagnosis dictionaries are selected by subject’s SNP types. (3. Evaluation of Proposed System) 3.1. Materials for experiment Specific disease is myocardial infarction, and variable element is systolic blood pressure. Numbers of onset samples are 1461 persons and non-onset samples are 649 persons to generate diagnosis dictionaries. The number of samples is 6 persons and these biomarker values are made even. 3.2. Experimental Result Figure 2 shows that the onset risk of acute myocardial infarction is different for each subject (SNPs type) under the same systolic blood pressure. Figure 2 Experimental Result I am considering that the result would become more appropriate for medical doctors. (4. Conclusions) We proposed a new health check system using SNPs and biomarkers. We will consider the other disease.(References)[1]GenoMarker,G&GScienceCo, http://www.genomarker.jp/index.html [2] Yoshiji Yamada, Hitoshi Matsuo, Sachiro Watanabe, Kimihiko Kato, Takeshi Hibino, Kiyoshi Yokoi, Sahoko Ichihara, Norifumi Metoki, Hidemi Yoshida, Kei Satoh, Yoshinori Nozawa. : Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus.Int J Mol Med, Vol.20, No.5, pp.703-707, (2007) | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 三重大学大学院地域イノベーション学研究科博士前期課程地域イノベーション学専攻 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 39 | |||||
書誌情報 |
発行日 2013-01-01 |
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フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
Health Check Support System Using Relationship between Individual Genome Information (SNP) and Lifestyle Disease | ||||||
出版者 | ||||||
出版者 | 三重大学 | |||||
出版者(ヨミ) | ||||||
ミエダイガク | ||||||
修士論文指導教員 | ||||||
姓名 | 鶴岡, 信治 | |||||
言語 | ja | |||||
資源タイプ(三重大) | ||||||
Master's Thesis / 修士論文 |