{"_buckets": {"deposit": "c7ab1680-7110-44be-ae5c-07cf41630023"}, "_deposit": {"created_by": 15, "id": "12433", "owners": [15], "pid": {"revision_id": 0, "type": "depid", "value": "12433"}, "status": "published"}, "_oai": {"id": "oai:mie-u.repo.nii.ac.jp:00012433", "sets": ["1692670416720"]}, "author_link": [], "item_8_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2017-05-18", "bibliographicIssueDateType": "Issued"}}]}, "item_8_description_14": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_8_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "難治癌の一つである進行膵癌に対して、超音波内視鏡下針生検にて得られた診断時のサンプルを用いて、個別化治療を推進するための新しいバイオマーカーを見いだし、その有用性を研究した。まず、Human equilibrative nucleoside transporter (hENT1)は抗癌剤GEMの主要な腫瘍細胞内輸送蛋白であるが、このhENT1発現を針生検のサンプルを用いて、抗癌剤感受性を調べ、治療と予後予測に役立てた。また、別の抗癌剤TS1についても、治療前にdihydropyrimidine dahydrogenase (DPD)発現を調べることにより、同様な役割を果たせることを証明した。 ", "subitem_description_type": "Abstract"}, {"subitem_description": "By using Endoscopic Ultrasonography-Guided Fine-Needle Aspiration Biopsy (EUS-FNAB) samples, we planed to establish personalized treatment for advanced pancreatic cancer. First we evaluated the relationship between Human equilibrative nucleoside transporter (hENT1) expressions assessed by immunohistochemical staining and clinical outcomes. We could discriminate whether the patients had a sensitivity of chemotherapy (gemcitabine) or not. In addition, we investigated immunohistochemical staining of dihydropyrimidine dehydrogenase (DPD: enzyme involved in the degradation of tegafur), and we revealed that DPD was useful of chemo sensitivity for TS-1.", "subitem_description_type": "Abstract"}]}, "item_8_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "2013年度~2016年度科学研究費補助金(基盤研究(C))研究成果報告書", "subitem_description_type": "Other"}]}, "item_8_description_64": {"attribute_name": "科研費番号", "attribute_value_mlt": [{"subitem_description": "25461033", "subitem_description_type": "Other"}]}, "item_8_publisher_30": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "三重大学"}]}, "item_8_text_31": {"attribute_name": "出版者(ヨミ)", "attribute_value_mlt": [{"subitem_text_value": "ミエダイガク"}]}, "item_8_text_65": {"attribute_name": "資源タイプ(三重大)", "attribute_value_mlt": [{"subitem_text_value": "Kaken / 科研費報告書"}]}, "item_8_version_type_15": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "伊佐地, 秀司", "creatorNameLang": "ja"}, {"creatorName": "ISAJI, Shuji", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "水野, 修吾", "creatorNameLang": "ja"}, {"creatorName": "MIZUNO, Shugo", "creatorNameLang": "en"}]}, {"creatorNames": [{"creatorName": "山田, 玲子", "creatorNameLang": "ja"}, {"creatorName": "YAMADA, Reiko", "creatorNameLang": "en"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2019-05-08"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "2018RP0043.pdf", "filesize": [{"value": "1.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_note", "mimetype": "application/pdf", "size": 1200000.0, "url": {"label": "2018RP0043", "url": "https://mie-u.repo.nii.ac.jp/record/12433/files/2018RP0043.pdf"}, "version_id": "d62052d5-f6fc-4edf-8b14-93f4bf227cbc"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "膵癌", "subitem_subject_scheme": "Other"}, {"subitem_subject": "EUS-FNAB", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "research report", "resourceuri": "http://purl.org/coar/resource_type/c_18ws"}]}, "item_title": "EUS-FNA検体を用いた、新たな膵癌集学的治療戦略", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "EUS-FNA検体を用いた、新たな膵癌集学的治療戦略", "subitem_title_language": "ja"}, {"subitem_title": "Novel strategy for treatment of pancreatic cancer by using EUS-FNAB samples", "subitem_title_language": "en"}]}, "item_type_id": "8", "owner": "15", "path": ["1692670416720"], "permalink_uri": "http://hdl.handle.net/10076/00018065", "pubdate": {"attribute_name": "PubDate", "attribute_value": "2019-05-08"}, "publish_date": "2019-05-08", "publish_status": "0", "recid": "12433", "relation": {}, "relation_version_is_last": true, "title": ["EUS-FNA検体を用いた、新たな膵癌集学的治療戦略"], "weko_shared_id": -1}
EUS-FNA検体を用いた、新たな膵癌集学的治療戦略
http://hdl.handle.net/10076/00018065
http://hdl.handle.net/10076/00018065