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大腸癌腹膜播種に関与するmicroRNAの網羅的解析と治療戦略
http://hdl.handle.net/10076/00018901
http://hdl.handle.net/10076/00018901b21538ae-2e08-4766-9601-298345efca42
名前 / ファイル | ライセンス | アクション |
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2019RP0057 (442.6 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-01-22 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 大腸癌腹膜播種に関与するmicroRNAの網羅的解析と治療戦略 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Comprehensive analysis of microRNAs associated with peritoneal dissemination of colorectal cancer and treatment strategy | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 大腸癌 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 腹膜播種 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | microRNA | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
著者 |
藤川, 裕之
× 藤川, 裕之× 問山, 裕二× 井上, 靖浩× 楠, 正人 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 大腸癌腹膜播種進展ひいては転移進展の診断マーカーとその機序を解明するために、大腸癌腹膜播種患者の原発組織ならびに、血清microRNA の網羅的解析を行った。とくに大腸癌患者血清と健常人血清の比較において大腸癌患者血清で有意に発現上昇するmiR-1290が、癌進展にかかわるoncogenic miRNAであることを確認するとともに、組織においてのみならず血清において大腸癌患者で有意に発現上昇し、有用な早期診断・予後マーカーであった。さらに血清miR-1290は腹膜播種転移陽性患者群で有意に発現上昇をし、腹膜播種診断マーカーとして有用である可能性が示唆された。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To identify miRNA biomakers for peritoneal metastasis in colorectal cancerand to clarify the funtional mechanism of these miRNAs for development of peritoneal metastasis, weperformed array-based comprehesive analysis. From this result, we demonstrated that serum miR-1290was significantly increased in CRC patients compared to healthy volunteers, and increased serummiR-1290 was significantly correlated with recurrence and poor survival in CRC. Especially, serummiR-1290 was significantly increased in CRC patients harboring peritoneal metastasis, and suggestedthat serum miR-1290 might be used as a predictive biomarker for peritoneal metastasis in CRCpatients. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2015年度~2017年度科学研究費補助金(基盤研究(C))研究成果報告書 | |||||
書誌情報 |
発行日 2018-05-24 |
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フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 三重大学 | |||||
出版者(ヨミ) | ||||||
ミエダイガク | ||||||
科研費番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 15K10134 | |||||
資源タイプ(三重大) | ||||||
Kaken / 科研費報告書 |