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聴覚変化検出からみたうつ病の神経基盤
http://hdl.handle.net/10076/00018911
http://hdl.handle.net/10076/000189115edc12c8-ecb9-4478-ab33-383373fb34b6
名前 / ファイル | ライセンス | アクション |
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2019RP0070 (525.3 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2020-01-22 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 聴覚変化検出からみたうつ病の神経基盤 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | The neural basis of depression based on the auditory change detection | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | うつ病 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 誘発電位 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 誘発磁場 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 変化関連脳活動 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
著者 |
元村, 英史
× 元村, 英史× 前田, 正幸× 乾, 幸二× 谷井, 久志× 城山, 隆 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 変化関連脳活動は脳波や脳磁図で明瞭に記録することができ、基本的かつ重要な脳内情報処理過程を反映するものである。本研究では変化関連脳活動を用いてうつ病の神経基盤の解明を目指し、以下のことを明らかにした。(1)変化関連脳活動は不安・抑うつの性格特性と関連がある。(2) BDNF遺伝子多型において、Met キャリア健常者ではVal/Val型健常者と比較してOFF反応の振幅が高かった。(3) うつ病患者では、健常者と比較して変化関連脳活動強度は強かった。これらの結果から過剰な変化検出がうつ病の素因のひとつに挙げられるのではないかと考える。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The change-related cerebral response, an auditory evoked potential measured by electroencephalography (EEG) or magnetoencephalography (MEG), is speculated to reflect the neural processing of sensory changes, which is essential for survival. Here we investigated the neural basis of depression by using the change-related cerebral response. We obtained the following findings. (1) The change-related response might be affected by personality traits, particularly anxiety- or depression-related traits. (2) The healthy subjects with Met carrier showed significantly higher amplitudes of the off-response compared to subjects with Val/Val in the BDNF polymorphisms. (3) The amplitude of the change-related response was significantly higher in the depressive patients compared to the healthy controls. These results suggest that high sensitivity of the change detection system might be a feature of predisposition to depression. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 2013年度~2017年度科学研究費補助金(基盤研究(C))研究成果報告書 | |||||
書誌情報 |
発行日 2018-06-15 |
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フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
出版者 | ||||||
出版者 | 三重大学 | |||||
出版者(ヨミ) | ||||||
ミエダイガク | ||||||
科研費番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 25461763 | |||||
資源タイプ(三重大) | ||||||
Kaken / 科研費報告書 |