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神経堤と中胚葉を標識できるマウスを用いた歯髄及び骨髄幹細胞の起源と性状の解明
http://hdl.handle.net/10076/13718
http://hdl.handle.net/10076/1371869da7fb3-54c8-4182-a1cf-556dcf4a6150
名前 / ファイル | ライセンス | アクション |
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30K16757.pdf (341.0 kB)
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Item type | 報告書 / Research Paper(1) | |||||
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公開日 | 2014-03-10 | |||||
タイトル | ||||||
言語 | ja | |||||
タイトル | 神経堤と中胚葉を標識できるマウスを用いた歯髄及び骨髄幹細胞の起源と性状の解明 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 神経堤細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 中胚葉 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 間葉系幹細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 歯髄細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 骨髄間葉系細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 象牙芽細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 胚性幹細胞 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 細胞系譜追跡 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_18ws | |||||
資源タイプ | research report | |||||
著者 |
山崎, 英俊
× 山崎, 英俊× 山根, 利之 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 中胚葉或いは神経堤由来細胞を蛍光標識できるマウスを用いて歯の間葉の大部分が神経堤細胞に、骨髄の間葉細胞の半分が中胚葉由来及び神経堤に由来する細胞からなることを明らかにした。また、間葉系幹細胞の検出法であるColony-Forming Unit Fibroblast(CFU-F)アッセイにより歯のCFU-F形成細胞は主に神経堤に、骨髄のCFU-F形成細胞は神経堤のみならず、中胚葉に由来する細胞からなることを明らかにした。また歯髄の間葉細胞が骨髄の間葉細胞と同様にB細胞や破骨細胞の分化を支持する能力を持つ事を見いだした。 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | By using transgenic mouse which enabled us to trace NC-derived or mesodermal cells, we showed that dental mesenchyme was composed of mainly NC-derived cells, whereas half of bone marrow(BM) mesenchyme was composed of cells other than NC-derived and mesodermal cells. Furthremore, a colony-forming unit-fibroblast(CFU-F) assay indicated that CFU-Fs in the dental pulp are derived from NC, and BM are derived from both NC and mesodermal cells. Furthermore, we showed that dental mesenchyme supported the differentiation of B lymphocytes and osteoclasts. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 平成22~23年度科学研究費補助金(挑戦的萌芽研究)研究成果報告書 | |||||
書誌情報 |
発行日 2012-05-21 |
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フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
Analysis of the origin and properties of dental and bone marrow mesenchymal stem cells by using mice to label NC-derived and mesodermal cells | ||||||
出版者 | ||||||
出版者 | 三重大学 | |||||
科研費番号 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 21659422 | |||||
資源タイプ(三重大) | ||||||
Kaken / 科研費報告書 |