@article{oai:mie-u.repo.nii.ac.jp:00010778,
 author = {卯川, 裕一 and Ukawa, Yuuichi and 小嶋, 靖 and Kojima, Yasushi and 杣, 佳次郎 and Soma, Keijiro and 三島, 隆 and Mishima, Takashi and 久松, 眞 and Hisamatsu, Makoto},
 issue = {3},
 journal = {日本食品科学工学会誌 : Nippon shokuhin kagaku kogaku kaishi = Journal of the Japanese Society for Food Science and Technology},
 month = {Mar},
 note = {application/pdf, An extract of Hatakeshimeji (Lyophyllum decastes Sing.) was orally administrated once to male and female mice and to male mice for 20 weeks. We macroscopically observed general symptoms, the presence or absence of death during a dose period, and the presence or absence of abnormality upon completion. Results suggest that the general observation of symptoms and increase of weight were unchanged and no death or abnormal findings were present at autopsy.In addition, the extract of Hatakeshimeji (2.88g) was administrated orally to 11 adults for two weeks during which we assessed its safety by conducting blood tests, urine tests, and blood pressure and body measurement checks. Consequently, there were no clinical problems observed with regard to blood test results, hepatic and renal functions, glucose and lipid metabolisms, and blood pressure. Likewise, analysis of agaritine from hot-water extracts of Hatakeshimeji showed no such problems. These results suggest that the extract of Hatakeshimeji is a safe food and may perform some health functions., ハタケシメジ抽出エキスをマウスに単回経口投与もしくは20週間継続的に摂取し，投与期間中の一般症状と死亡の有無を観察するとともに，観察終了日に病理解剖を行い，異常の有無を肉眼的に観察した．その結果，ハタケシメジ抽出エキス投与群では，対照群と同様，一般症状，体重増加推移に変化はなく，異常な剖検所見や死亡は観察されなかった．さらに，ハタケシメジ熱水抽出エキスを成人1日あたり2.88g, 2週間摂取し，血液検査，尿検査，血圧・身体測定および問診から安全性について検討した結果，血液学検査，肝機能，腎機能，糖代謝，脂質代謝，血圧および身体検査の各試験項目において，臨床上問題となる異常所見の発現は一切認められなかった．また，アガリチンについて，ハタケシメジ熱水抽出エキスに含まれるか否かを分析した結果，検出限界2ngで検出されなかった．以上の結果，ハタケシメジ抽出エキスは，安全性の高い食品であり，生活習慣病の1次予防の手段としてハタケシメジの利用が期待される．},
 pages = {133--137},
 title = {ハタケシメジ熱水抽出物の安全性評価},
 volume = {54},
 year = {2007}
}