{"created":"2023-06-19T11:41:53.364916+00:00","id":10849,"links":{},"metadata":{"_buckets":{"deposit":"12445cb2-53d4-432a-a769-1a9173335a1d"},"_deposit":{"created_by":15,"id":"10849","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"10849"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00010849","sets":["515:756:1692665128869"]},"author_link":["27158"],"control_number":"10849","item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-02-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究により、前立腺間質PrSCではTGFβシグナルの活性化に伴う筋線維芽細胞様の分化誘導が、間質由来KGF mRNAの産生を低下させることが判明した。よって、再燃前立腺癌の増殖過程では、癌細胞を取り巻く間質細胞の種類が重要であると考えられた。","subitem_description_type":"Abstract"},{"subitem_description":"Our results showed that TGFβ-induced myofibroblastic differentiation in PrSC reduced the expression of KGF mRNA. Thus, we suggest that type of stromal cells surrounding cancer cells may be important in the progression of castration resistant prostate cancer.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"平成21~22年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21791499","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"A new therapeutic strategy for targeting carcinoma-associated fibroblast-derived KGF in castration resistant prostate cancer"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石井, 健一朗","creatorNameLang":"ja"},{"creatorName":"ISHII, Kenichiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27158","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-20"}],"displaytype":"detail","filename":"60K16748.pdf","filesize":[{"value":"393.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"60K16748.pdf","url":"https://mie-u.repo.nii.ac.jp/record/10849/files/60K16748.pdf"},"version_id":"c2477bae-3bbd-4392-a608-7648f4ee259b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"再燃前立腺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"癌間質","subitem_subject_scheme":"Other"},{"subitem_subject":"KGF","subitem_subject_scheme":"Other"},{"subitem_subject":"線維芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"筋線維芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"TGFβ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌間質由来ＫＧＦを標的とした再燃前立腺癌の新規治療戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌間質由来ＫＧＦを標的とした再燃前立腺癌の新規治療戦略","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692665128869"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-03-10"},"publish_date":"2014-03-10","publish_status":"0","recid":"10849","relation_version_is_last":true,"title":["癌間質由来ＫＧＦを標的とした再燃前立腺癌の新規治療戦略"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-21T02:56:04.513648+00:00"}