{"created":"2023-06-19T11:41:53.448084+00:00","id":10851,"links":{},"metadata":{"_buckets":{"deposit":"458995dd-c0a9-4e87-9f06-f6bb542af475"},"_deposit":{"created_by":15,"id":"10851","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"10851"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00010851","sets":["515:756:1692664452376"]},"author_link":["27174","27176"],"control_number":"10851","item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-06-05","bibliographicIssueDateType":"Issued"}}]},"item_8_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"多田, 佐枝子","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"27176","nameIdentifierScheme":"WEKO"}]}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"食品に含有するナノ粒子の消化器系における炎症反応の誘導作用を解明するため、ヒトマクロファージ様細胞THP-1および大腸腺癌細胞Caco-2を用い、ナノ粒子曝露による生存率の変化、活性酸素種（ROS）および炎症性サイトカインの産生について解析を行った。二酸化チタンのナノ粒子曝露により、ROSおよび炎症性サイトカインIL-1βの産生が増加する傾向が認められた。また一次粒径が同程度でも、酸化亜鉛の方が二酸化チタンより細胞の生存率の低下およびROSの産生を誘導する事が認められ、粒子の種類により細胞毒性作用、炎症反応誘導の機構に違いがあることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"The present study investigated the cytotoxicity, production of reactive oxygen species (ROS) and inflammatory cytokine induced by nano-TiO₂ and nano-ZnO particles using human monocytic leukemia cells (THP-1) and human colon cancer cells (Caco-2). The viability of THP-1 macrophages exposed to nano-ZnO was lower than that to nano-TiO₂ THP-1. The production of ROS and IL-1β showed a tendency to be increased by nano-TiO₂ particles. This study indicated that nano-TiO₂ particles may induce inflammation in THP-1 macrophages through production of ROS and IL-1β, and nano- ZnO particles were suggested to be more toxic to THP-1 macrophages than nano-TiO₂.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2011年度～2012年度科学研究費補助金(研究活動スタート支援)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"23890082","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_18":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_text_value":"Analysis and risk assessment of intestinal inflammation induced by food-containing nanoparticles."}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"及川, 佐枝子","creatorNameLang":"ja"},{"creatorName":"OIKAWA, SAEKO","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"27174","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-02-20"}],"displaytype":"detail","filename":"60K17185.pdf","filesize":[{"value":"430.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"60K17185.pdf","url":"https://mie-u.repo.nii.ac.jp/record/10851/files/60K17185.pdf"},"version_id":"720087f2-1426-46f5-9ebd-7fc3de58092e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ナノ粒子","subitem_subject_scheme":"Other"},{"subitem_subject":"二酸化チタン","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化亜鉛","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"食品含有ナノ粒子による腸管免疫機構の破綻を介した消化管炎症反応の解明とリスク評価","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"食品含有ナノ粒子による腸管免疫機構の破綻を介した消化管炎症反応の解明とリスク評価","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"15","path":["1692664452376"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-12-18"},"publish_date":"2014-12-18","publish_status":"0","recid":"10851","relation_version_is_last":true,"title":["食品含有ナノ粒子による腸管免疫機構の破綻を介した消化管炎症反応の解明とリスク評価"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-21T04:33:07.024798+00:00"}