{"created":"2023-06-19T11:42:12.574715+00:00","id":11313,"links":{},"metadata":{"_buckets":{"deposit":"7c3a3595-8c00-4df3-b9ff-11ae7bcf3d95"},"_deposit":{"created_by":16,"id":"11313","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"11313"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011313","sets":["334:608:618:833"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-25","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-25"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The assessment of human epidermal growth factor receptor 2 (HER2) status is crucial for selecting with patients with gastric cancer who may benefit from HER2-targeted therapy. Accurate assessment using biopsy specimens is important for patients with advanced-stage cancer. Intratumoral heterogeneity of HER2, however, is a major challenge in HER2 testing. Here, we aimed to examine whether assessment of HER2 status could be accurately performed with currently used methods, i.e., immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and dual-color in situ hybridization (DISH).  HER2 status was evaluated in 108 biopsy tissues from patients with gastric adenocarcinoma and 70 matched surgical specimens by IHC, FISH, and DISH. HER2 amplification was detected in 11 (10.2%) out of 108 biopsy specimens. IHC and FISH . IHC and FISH . IHC and FISH . IHC and FISH . IHC and FISH . IHC and FISH . IHC and FISH . IHC and FISH . IHC and FISH results were well correlated, and FISH and DISH results were consistent for all cases. The overall concordance rate of HERS status between biopsy tissues and surgical specimens was  91.4%. All six discordant cases were false negative on biopsy; of these cases, five showed HER2 heterogeneity on surgical resection. Assessment of the HER2 status of biopsy tissues could predict the status of the whole tumor; however a proportion of these cases may be discordant because of intratumoral heterogeneity.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文 / Department of Oncologic Pathology, Mie University Graduate School of Medicine","subitem_description_type":"Other"},{"subitem_description":"26p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第1761号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1111/cas.12886","subitem_relation_type_select":"DOI"}}]},"item_7_relation_37":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://onlinelibrary.wiley.com/doi/10.1111/cas.12886/full"}]}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Cancer Science, 107 (4), 2016, pp. 536-542, ISSN : 1349-7006 に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kanayama, Kazuki","creatorNameLang":"en"},{"creatorName":"カナヤマ, カズキ","creatorNameLang":"ja-Kana"},{"creatorName":"金山, 和樹","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-07-04"}],"displaytype":"detail","filename":"2015DM024.pdf","filesize":[{"value":"373.3 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2015DM024","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/11313/files/2015DM024.pdf"},"version_id":"4cbe8c8a-095c-4940-9623-8e2e50692090"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Human epidermal growth factor receptor 2","subitem_subject_scheme":"Other"},{"subitem_subject":"intratumoral heterogeneity","subitem_subject_scheme":"Other"},{"subitem_subject":"biopsy specimens","subitem_subject_scheme":"Other"},{"subitem_subject":"dual-color in situ hybridization","subitem_subject_scheme":"Other"},{"subitem_subject":"gastric cancer","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Significant intratumoral heterogeneity of HER2 status in gastric cancer: a comparative study among IHC, FISH, and DISH","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Significant intratumoral heterogeneity of HER2 status in gastric cancer: a comparative study among IHC, FISH, and DISH","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["833"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-07-04"},"publish_date":"2017-07-04","publish_status":"0","recid":"11313","relation_version_is_last":true,"title":["Significant intratumoral heterogeneity of HER2 status in gastric cancer: a comparative study among IHC, FISH, and DISH"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-11-06T04:42:50.390719+00:00"}