@phdthesis{oai:mie-u.repo.nii.ac.jp:00011320,
 author = {Yamada, Reiko and 山田, 玲子},
 month = {Mar},
 note = {application/pdf, Objectives: To clarify whether pretreatment human equilibrative nucleoside transporter  (hENTl) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline resectable, and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those in the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT), and to validate the utility of hENT1 expression using EUS-FNAB samples as a prognostic marker. Methods: We evaluated the relationship between hENT1 expressions assessed by immunohistochemical staining and clinical outcomes in the 51 of 76 PDAC patients who were diagnosed by EUS-FNAB and received preoperative Gem-CRT. Results: The concordance rate of hENT1 expressions was 89.2% (K=0.681). Median survival time (month) in the 51 whole patients and 37 with resection was significantly longer in hENT1 positive than in negative: 25.0 and 30.0 vs. 9.0 and 9.0, respectively. A multivariate analysis confirmed that hENT1 expression was an independent prognostic factor in both whole patients and those with resection. Regardless of T3 and T4, hENT1-positive patients with resection had significantly better prognosis than negative patients , whose prognosis was similar to those without resection. Conclusions: The assessment of hENT1 expression using EUS-FNAB samples prior to Gem-CRT provides important information on PDAC patients who can benefit from curative-intent resection ., 本文 / Gastroenterology and Hepatology, Mie University Graduate School of Medicine, 55p},
 school = {三重大学},
 title = {Human equilibrative nucleoside transporter-1 (hENT1) expression in endoscopic ultrasonography-guided fine-needle aspiration biopsy samples is a strong predictor of clinical response and survival in the patients with pancreatic ductal adenocarcinoma undergoing gemcitabine-based chemoradiotherapy},
 year = {2016},
 yomi = {ヤマダ, レイコ}
}