{"created":"2023-06-19T11:42:12.872696+00:00","id":11320,"links":{},"metadata":{"_buckets":{"deposit":"bb39a4a1-ab45-41b5-b32f-f2006dba1356"},"_deposit":{"created_by":16,"id":"11320","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"11320"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011320","sets":["334:608:618:833"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-25","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-25"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: To clarify whether pretreatment human equilibrative nucleoside transporter  (hENTl) expressions in endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNAB) specimens obtained from resectable, borderline resectable, and locally advanced unresectable pancreatic ductal adenocarcinoma (PDAC) are concordant with those in the resected specimen after gemcitabine-based chemoradiotherapy (Gem-CRT), and to validate the utility of hENT1 expression using EUS-FNAB samples as a prognostic marker. Methods: We evaluated the relationship between hENT1 expressions assessed by immunohistochemical staining and clinical outcomes in the 51 of 76 PDAC patients who were diagnosed by EUS-FNAB and received preoperative Gem-CRT. Results: The concordance rate of hENT1 expressions was 89.2% (K=0.681). Median survival time (month) in the 51 whole patients and 37 with resection was significantly longer in hENT1 positive than in negative: 25.0 and 30.0 vs. 9.0 and 9.0, respectively. A multivariate analysis confirmed that hENT1 expression was an independent prognostic factor in both whole patients and those with resection. Regardless of T3 and T4, hENT1-positive patients with resection had significantly better prognosis than negative patients , whose prognosis was similar to those without resection. Conclusions: The assessment of hENT1 expression using EUS-FNAB samples prior to Gem-CRT provides important information on PDAC patients who can benefit from curative-intent resection .","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文 / Gastroenterology and Hepatology, Mie University Graduate School of Medicine","subitem_description_type":"Other"},{"subitem_description":"55p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第1770号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1097/MPA.0000000000000597","subitem_relation_type_select":"DOI"}}]},"item_7_relation_37":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://journals.lww.com/pancreasjournal/Fulltext/2016/05000/Human_Equilibrative_Nucleoside_Transporter_1.19.aspx"}]}]},"item_7_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2016 Wolters Kluwer Health, Inc. All rights reserved."}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Pancreas, 45 (5), 2016, pp761-771, ISSN : 0885-3177 に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamada, Reiko","creatorNameLang":"en"},{"creatorName":"ヤマダ, レイコ","creatorNameLang":"ja-Kana"},{"creatorName":"山田, 玲子","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-07-04"}],"displaytype":"detail","filename":"2015DM033.pdf","filesize":[{"value":"11.4 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2015DM033","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/11320/files/2015DM033.pdf"},"version_id":"e00e2ce7-7201-4af0-8d7d-a5cbc3da9e28"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"EUS-FNAB","subitem_subject_scheme":"Other"},{"subitem_subject":"hENT1","subitem_subject_scheme":"Other"},{"subitem_subject":"chemoradiotherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"gemcitabine","subitem_subject_scheme":"Other"},{"subitem_subject":"pancreatic ductal adenocarcinoma","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Human equilibrative nucleoside transporter-1 (hENT1) expression in endoscopic ultrasonography-guided fine-needle aspiration biopsy samples is a strong predictor of clinical response and survival in the patients with pancreatic ductal adenocarcinoma undergoing gemcitabine-based chemoradiotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Human equilibrative nucleoside transporter-1 (hENT1) expression in endoscopic ultrasonography-guided fine-needle aspiration biopsy samples is a strong predictor of clinical response and survival in the patients with pancreatic ductal adenocarcinoma undergoing gemcitabine-based chemoradiotherapy","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["833"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-07-04"},"publish_date":"2017-07-04","publish_status":"0","recid":"11320","relation_version_is_last":true,"title":["Human equilibrative nucleoside transporter-1 (hENT1) expression in endoscopic ultrasonography-guided fine-needle aspiration biopsy samples is a strong predictor of clinical response and survival in the patients with pancreatic ductal adenocarcinoma undergoing gemcitabine-based chemoradiotherapy"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-11-06T04:43:07.364563+00:00"}