{"created":"2023-06-19T11:42:12.915075+00:00","id":11321,"links":{},"metadata":{"_buckets":{"deposit":"d40e90ad-f039-4a09-9760-8821c0f5547e"},"_deposit":{"created_by":16,"id":"11321","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"11321"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011321","sets":["334:608:618:833"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-03-25","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-03-25"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and Aims: Amino acid metabolites including branched chain amino acids (BCAA) and tyrosine (Tyr) affect glucose metabolism. The effects of BCAA on insulin resistance in patients with diabetes seem to conflict with mechanisms determined in animal models and cultured cells. We investigated the physiological effects of BCAA and Tyr on glucose metabolism among healthy community dwellers to clarify the controversy surrounding the effects of BCAA. Participant and methods: We investigated associations among BCAA and Tyr and metabolic parameters in 78 residents (median age, 52 y) of Mie, Japan who did not have pre-diabetes, diabetes, or a BMI > 30 kg/m2. Results: Muscle volume, serum BCAA and Tyr levels were higher in men than in women (n=32 and 46, respectively; all p < 0.0001). Stepwise multiple regression analysis associated BCAA positively with muscle volume (regression coefficient/t/p/ 95%CI=281.8/ 3.7/ 0.0004/ 129.7-433.8), fasting blood glucose (FBG) (12699.4/ 3.22/ 0.0020/ 4830.9-20567.8), fasting immunoreactive insulin (IRI) (8505.1/ 2.75/ 0.0078/ 2322.5-14687.6) and homeostasis model assessment of β cell function (HOMA-β) (893.6/ 2.58/ 0.0122/ 201.8-1585.5), and negatively with the HOMA-insulin resistance (HOMA-IR) (-9294.1/ -2.89/ 0.0052/ -15711.0- -2877.1). Tyr positively correlated with fasting IRI (26.0/ 2.77/ 0.0072/ 7.3-44.7). Conclusions: Insulin sensitivity and muscle volume are positively associated with BCAA in individuals without diabetes. In turn, BCAA correlate with increased FBG and fasting IRI levels. Tyr correlated with fasting IRI, but not with insulin sensitivity.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文 / Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine","subitem_description_type":"Other"},{"subitem_description":"27p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第1772号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.nut.2015.11.003","subitem_relation_type_select":"DOI"}}]},"item_7_relation_37":{"attribute_name":"関係URI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://doi.org/10.1016/j.nut.2015.11.003"}]}]},"item_7_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2016 Elsevier Inc. All rights reserved."}]},"item_7_text_31":{"attribute_name":"出版者(ヨミ)","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Nutrition, 32 (5), 2016, pp. 531-538, ISSN : 0914-5087 に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ(三重大)","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Honda, Tatsuro","creatorNameLang":"en"},{"creatorName":"ホンダ, タツロウ","creatorNameLang":"ja-Kana"},{"creatorName":"本田, 達朗","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-07-04"}],"displaytype":"detail","filename":"2015DM035.pdf","filesize":[{"value":"232.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2015DM035","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/11321/files/2015DM035.pdf"},"version_id":"8f845095-0b9f-41be-81b8-6fef6e7a6115"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"insulin resistance","subitem_subject_scheme":"Other"},{"subitem_subject":"β cell function","subitem_subject_scheme":"Other"},{"subitem_subject":"fasting blood glucose","subitem_subject_scheme":"Other"},{"subitem_subject":"Spearman’s test","subitem_subject_scheme":"Other"},{"subitem_subject":"stepwise multiple regression analysis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Associations among circulating branched-chain amino acids and tyrosine with muscle volume and glucose metabolism in individuals without diabetes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Associations among circulating branched-chain amino acids and tyrosine with muscle volume and glucose metabolism in individuals without diabetes","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["833"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-07-04"},"publish_date":"2017-07-04","publish_status":"0","recid":"11321","relation_version_is_last":true,"title":["Associations among circulating branched-chain amino acids and tyrosine with muscle volume and glucose metabolism in individuals without diabetes"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-11-06T04:43:09.387342+00:00"}