{"created":"2023-06-19T11:42:18.505869+00:00","id":11465,"links":{},"metadata":{"_buckets":{"deposit":"a2b7955b-8ca5-436b-972e-67d38fc1dfcf"},"_deposit":{"created_by":16,"id":"11465","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"11465"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011465","sets":["334:608:618:843"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-09-21","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-09-21"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objective: To investigate the effect of a novel topical wound-healing agent, low-concentration povidone-iodine ointment (LPIO) with a hydrophobic white petrolatum-rich base, on skin-wound models in rats and rabbits. Methods: We investigated the therapeutic efficacy of topically applied LPIO compared to that of standard-concentration povidone-iodine ointment (SPIO) and non-treatment control, using a full-thickness skin-wound model in hairless rats and a full-thickness skin-defect model in rabbit earlobes. Therapeutic efficacy was evaluated based on macroscopic wound-size reduction, as well as histopathological and immuno-histochemical examinations. Results: LPIO enhanced wound healing in rat full-thickness skin ulcers, reducing wound size and inflammation, when compared with that in SPIO and non-treatment control. LPIO also markedly improved wound healing in rabbit earlobe ulcers by significantly improving re-epithelialisation, compared with that in SPIO. Conclusions: The results of this study suggest that LPIO is a useful topical therapy for ulcerative lesions.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文 / Central Research Laboratory, Maruishi Pharmaceutical Co., Ltd.; Department of Dermatology, Mie University Graduate School of Medicine","subitem_description_type":"Other"},{"subitem_description":"24p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第1800号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.12968/jowc.2016.25.9.521 ","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Journal of Wound Care, 25(9), pp.521-529, 2016, ISSN: 0969-0700 に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mitani, Osamu","creatorNameLang":"en"},{"creatorName":"ミタニ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"三谷, 治","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-07"}],"displaytype":"detail","filename":"2016DM013.pdf","filesize":[{"value":"87.7 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2016DM013","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/11465/files/2016DM013.pdf"},"version_id":"347bdfdc-a5cb-4009-9f5c-84bed5b3c614"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Wound healing","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"PVP-I","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Wound model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Ointment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"White petrolatum","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Enhanced wound healing by topical application of ointment containing low concentration of povidone-iodine","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enhanced wound healing by topical application of ointment containing low concentration of povidone-iodine","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["843"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-11-07"},"publish_date":"2017-11-07","publish_status":"0","recid":"11465","relation_version_is_last":true,"title":["Enhanced wound healing by topical application of ointment containing low concentration of povidone-iodine"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-11-02T05:34:11.087920+00:00"}