{"created":"2023-06-19T11:42:18.590093+00:00","id":11467,"links":{},"metadata":{"_buckets":{"deposit":"8c1b8ddb-98bf-475b-9aca-9f6497918c04"},"_deposit":{"created_by":16,"id":"11467","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"11467"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011467","sets":["334:608:618:843"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12-21","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2016-12-21"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Diagnostic markers can facilitate more selective screening and treatment strategies for ulcerative colitis (UC)-associated cancer (UCAC). We analyzed trefoil factor-3 (TFF3), which has an important role in mucosal protection and repair in the gastrointestinal tract, and evaluated its significance for UCAC. We enrolled 145 patients with UC who underwent proctocolectomies including 15 patients (10.8%) with UCAC. We assessed TFF3 expression immunohistochemically in their rectal mucosa and in cancer cells, and compared their expression in UCAC and sporadic colorectal cancer. In testing mucinous granules of goblet cells located in crypts, we found that non-cancerous rectal mucosa of UCAC patients had significantly lower (P < 0.01) mean TFF3 staining scores (4.53 ± 2.36) than did specimens of patients with UC without UCAC (7.21 ± 3.38) or sporadic cancer (7.58 ± 2.72). TFF3 staining score was an independent predictor of UCAC development (odds ratio: 4.32, confidence interval: 1.01–29.9, P = 0.05). These results indicate that low TFF3 expression in rectal mucosa is associated with the development of UCAC. Thus, TFF3 in the rectal mucosa may be a useful biomarker for monitoring patients with UC.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文 / Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine","subitem_description_type":"Other"},{"subitem_description":"24p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第1809号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Oncology Letters, 2016 に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kondo, Satoru","creatorNameLang":"en"},{"creatorName":"コンドウ, サトル","creatorNameLang":"ja-Kana"},{"creatorName":"近藤, 哲","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-07"}],"displaytype":"detail","filename":"2016DM015.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2016DM015","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/11467/files/2016DM015.pdf"},"version_id":"f722e99c-587c-4122-8608-89c8656ae1e9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"trefoil factor-3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ulcerative colitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"colitis-associated cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"field effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"surveillance","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Down-regulation of trefoil factor-3 expression in the rectum is associated with the development of ulcerative colitis-associated cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Down-regulation of trefoil factor-3 expression in the rectum is associated with the development of ulcerative colitis-associated cancer","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["843"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-11-07"},"publish_date":"2017-11-07","publish_status":"0","recid":"11467","relation_version_is_last":true,"title":["Down-regulation of trefoil factor-3 expression in the rectum is associated with the development of ulcerative colitis-associated cancer"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-11-02T05:34:15.039782+00:00"}