{"created":"2023-06-19T11:42:19.093553+00:00","id":11479,"links":{},"metadata":{"_buckets":{"deposit":"ddf09686-8784-4724-a656-fefdb76b01b0"},"_deposit":{"created_by":16,"id":"11479","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"11479"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011479","sets":["334:608:618:843"]},"author_link":[],"control_number":"11479","item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-03-24","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2017-03-24"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ABSTRACT The beneficial effects of edible mushrooms for improving chronic intractable diseases have been documented. However, the antiatherogenic activity of the new medicinal mushroom Grifola gargal is unknown. Therefore, we evaluated whether Grifola gargal can prevent or delay the progression of atherosclerosis. Atherosclerosis was induced in ApoE lipoprotein- deficient mice by subcutaneous infusion of angiotensin II. Grifola gargal extract (GGE) was prepared and intraperitoneally injected. The weight of heart and vessels, dilatation/atheroma formation of thoracic and abdominal aorta, the percentage of peripheral granulocytes, and the blood concentration of MCP-1/CCL2 were significantly reduced in mice treated with GGE compared to untreated mice. By contrast, the percentage of regulatory T cells and the plasma concentration of SDF-1/CXCL12 were significantly increased in mice treated with the mushroom extract compared to untreated mice. In vitro, GGE significantly increased the secretion of SDF-1/CXCL12, VEGF, and TGF-b1 from fibroblasts compared to control. This study demonstrated for the first time that Grifola gargal therapy can enhance regulatory T cells and ameliorate atherosclerosis in mice.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文 / Department of Immunology, Mie University Graduate School of Medicine; Iwade Research Institute of Mycology","subitem_description_type":"Other"},{"subitem_description":"10p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第1824号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1089/jmf.2014.3315","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Journal of Medicinal Food, 18(8), 2015, pp. 872-881 ISSN: 1096-620X に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAlternatives":[{"creatorAlternative":"石井, 栄津子","creatorAlternativeLang":"ja"},{"creatorAlternative":"イシイ, エツコ","creatorAlternativeLang":"ja-Kana"}],"creatorNames":[{"creatorName":"Harada, Etsuko","creatorNameLang":"en"},{"creatorName":"ハラダ, エツコ","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-07"}],"displaytype":"detail","filename":"2016DM031.pdf","filesize":[{"value":"488.4 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2016DM031","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/11479/files/2016DM031.pdf"},"version_id":"84a960d1-7127-437e-8d27-e0982e15ecbc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"atheroma","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chemokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mushrooms","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"progenitor cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"remodeling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"regulatory T cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"vasculitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["843"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-11-07"},"publish_date":"2017-11-07","publish_status":"0","recid":"11479","relation_version_is_last":true,"title":["Amelioration of Atherosclerosis by the New Medicinal Mushroom Grifola gargal Singer"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-11-02T05:50:30.704180+00:00"}