{"created":"2023-06-19T11:42:30.012079+00:00","id":11739,"links":{},"metadata":{"_buckets":{"deposit":"76d6a5dc-cd0e-42fd-a923-6745fb139e12"},"_deposit":{"created_by":15,"id":"11739","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"11739"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011739","sets":["334:627:1692670396313"]},"author_link":["33819"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-17","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"炎症性腸炎では様々な血液細胞が大腸に浸潤し癌微小環境を形成することが知られているが、注目されるのは癌関連線維芽細胞（CAF）である。我々はこれまでに、単球がMCP-1/CCR2 axisを介して傷害臓器に浸潤して線維芽細胞や筋線維芽細胞様細胞に分化しうることを確認しており、CAFも単球由来ではないかとの仮説を立てた。EGFPマウスの骨髄細胞を移植したマウスにAOM/DSS傷害を与えると、炎症の進行に伴い傷害腸にEGFP陽性の単球と線維細胞・線維芽細胞が増加し、これらの細胞浸潤は腫瘍形成と関連していた。また、Angiotensin II受容体阻害薬投与は大腸線維化ならびに腫瘍形成を抑制した。","subitem_description_type":"Abstract"},{"subitem_description":"It is well known that several kinds of hematopoietic cells infiltrate the colon and form tumor microenvironment in inflammatory colitis. The cells, which have received the most attention as a key player in the microenvironment, are cancer-associated fibroblasts (CAFs). Because we have previously identified that monocytes enter the injured organs through MCP-1/CCR2 axis and differentiate into fibroblasts or myofibroblasts, we hypothesize that CAFs also are derived from monocytes. In C57BL/6J-Ly5.1 mice transplanted with EGFP+ bone marrow cells, EGFP+ fibrocytes and fibroblasts along with the inflammatory cells increased in the injured colon in association with progression of inflammation after AOM/DSS treatment. The increment of those cells was related to the formation of colon tumors. Angiotensin II receptor blocker, which exhibits antagonistic effects against CCR2, inhibited the progression of both colon fibrosis and tumor formation.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2013年度～2015年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"25460951","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"桝屋, 正浩","creatorNameLang":"ja"},{"creatorName":"マスヤ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"MASUYA, MASAHIRO","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-12"}],"displaytype":"detail","filename":"30K18148.pdf","filesize":[{"value":"378.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"30K18148","url":"https://mie-u.repo.nii.ac.jp/record/11739/files/30K18148.pdf"},"version_id":"2d2b5f46-8d32-409a-ac8b-7dd3b9907bd2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"monocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"MCP-1","subitem_subject_scheme":"Other"},{"subitem_subject":"fibrocyte","subitem_subject_scheme":"Other"},{"subitem_subject":"colon cancer","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"MCP-1およびテネイシンCによる造血細胞由来癌関連線維芽細胞の動員と大腸癌進展","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"MCP-1およびテネイシンCによる造血細胞由来癌関連線維芽細胞の動員と大腸癌進展","subitem_title_language":"ja"},{"subitem_title":"Relationship between the recruitment of hematopoietic cell-derived cancer-associated fibroblasts by MCP-1 or tenascin C and the development of colon cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670396313"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-12"},"publish_date":"2018-01-12","publish_status":"0","recid":"11739","relation_version_is_last":true,"title":["MCP-1およびテネイシンCによる造血細胞由来癌関連線維芽細胞の動員と大腸癌進展"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-08T00:45:16.049615+00:00"}