{"created":"2023-06-19T11:42:30.577609+00:00","id":11752,"links":{},"metadata":{"_buckets":{"deposit":"03e34cc7-e391-45e6-9c2a-f822b6c2e489"},"_deposit":{"created_by":15,"id":"11752","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"11752"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011752","sets":["631:636:1692684709779"]},"author_link":[],"control_number":"11752","item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-12","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"核酸創薬は難治性疾患に対しての可能性を持ったものとして期待されている。我々は本邦オリジナルの独自の核酸を作成し、経気道的投与による呼吸器疾患への創薬を目指している。マウス疾患モデルを用いて核酸をデザインし、投与実験を行った結果、経気道的な核酸投薬によって疾患病態の制御が可能な事が分かった。今後日本発信の創薬開発につなげたい。","subitem_description_type":"Abstract"},{"subitem_description":"The nucleic acid innovative drug development is expected as a new therapeutic method for the refractory disease.We make the original nucleic acid as Japan original and aim at the innovative drug development to respiratory disease with the administration of the trans-airway.As a result of designing a nucleic acid using a mouse disease model, and having tested it, control of the disease clinical condition was found to be possible by a trans-airway nucleic acid medication.These results suggest that intra-tracheal instillation of RNAi agents may be useful for the therapy of pulmonary diseases.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2013年度～2015年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"25461189","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 哲","creatorNameLang":"ja"},{"creatorName":"コバヤシ, テツ","creatorNameLang":"ja-Kana"},{"creatorName":"KOBAYASHI, TETSU","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Gabazza, Esteban","creatorNameLang":"en"},{"creatorName":"ガバザ, エステバン","creatorNameLang":"ja"}]},{"creatorNames":[{"creatorName":"田口, 修","creatorNameLang":"ja"},{"creatorName":"タグチ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"TAGUCHI, OSAMU","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-12"}],"displaytype":"detail","filename":"39K18178.pdf","filesize":[{"value":"204.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K18178","url":"https://mie-u.repo.nii.ac.jp/record/11752/files/39K18178.pdf"},"version_id":"0a9987a6-aed7-4917-8ceb-52abe1983695"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"siRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"RNAi","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF","subitem_subject_scheme":"Other"},{"subitem_subject":"肺線維症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"RNAiを用いた難治性呼吸器疾患治療への創薬の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RNAiを用いた難治性呼吸器疾患治療への創薬の研究","subitem_title_language":"ja"},{"subitem_title":"RNAi for the treatment of refractory pulmonary diseases","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684709779"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-12"},"publish_date":"2018-01-12","publish_status":"0","recid":"11752","relation_version_is_last":true,"title":["RNAiを用いた難治性呼吸器疾患治療への創薬の研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-19T23:50:52.764297+00:00"}