{"created":"2023-06-19T11:42:30.751849+00:00","id":11756,"links":{},"metadata":{"_buckets":{"deposit":"3a386313-639f-451e-aaf9-80543d75fecb"},"_deposit":{"created_by":15,"id":"11756","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"11756"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011756","sets":["631:636:1692684709779"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-16","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"テネイシンC(TNC)の軟骨修復効果をみるため、家兎膝に骨軟骨欠損を作製し、硫酸化ジェラン固定化ジェランスポンジを担体としたTNCを投与したところ、良好な軟骨修復を認めた。マウスの膝に骨軟骨欠損を作製し、TNCを欠損部に直接投与しても良好な軟骨修復を認めた。軟骨変性抑制作用を調べるために、マウスの靱帯切離による変形性関節症モデルを作製し、TNCを投与すると6週まで軟骨変性が抑制されていた。すなわち、TNCは軟骨修復作用、軟骨変性抑制作用があることが示された。培養軟骨細胞にTNCを添加すると、ADAMTS4は発現量が増加したが、ADAMTS5は減少した。","subitem_description_type":"Abstract"},{"subitem_description":"We implanted Gellan-GS soaked in TNC into full-thickness osteochondral defects of the patellar groove of rabbits. Histologically as well as macroscopically, we found satisfactory repair of cartilage. Using mice, full-thickness osteochondral defects were created and the defects were filled with TNC. Histologic study showed satisfactory repair of cartilage. In posttraumatic osteoarthritis model with transection of anterior cruciate ligament and medial collateral ligament, we performed intra-articular injection of TNC. TNC administration markedly protected the articular cartilage from proteoglycan depletion for 6 weeks. These studies indicated that TNC could promote cartilage repair and protect cartilage degeneration in vivo. Although TNC upregulated the expression of ADAMTS4, TNC downregulated the expression of ADAMTS5.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2013年度～2015年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"25462367","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"長谷川, 正裕","creatorNameLang":"ja"},{"creatorName":"ハセガワ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"HASEGAWA, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"湏藤, 啓広","creatorNameLang":"ja"},{"creatorName":"スドウ, アキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"SUDO, Akihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉田, 利通","creatorNameLang":"ja"},{"creatorName":"ヨシダ, トシミチ","creatorNameLang":"ja-Kana"},{"creatorName":"YOSHIDA, Toshimichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-12"}],"displaytype":"detail","filename":"39K18183.pdf","filesize":[{"value":"245.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K18183","url":"https://mie-u.repo.nii.ac.jp/record/11756/files/39K18183.pdf"},"version_id":"abc52b91-7548-4483-8b69-8f5dbafc9eca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"関節軟骨","subitem_subject_scheme":"Other"},{"subitem_subject":"テネイシン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"関節軟骨に対するテネイシンCの修復促進・変性抑制の分子機構解明と治療への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"関節軟骨に対するテネイシンCの修復促進・変性抑制の分子機構解明と治療への応用","subitem_title_language":"ja"},{"subitem_title":"Mechanism of articular cartilage repair and prevention of cartilage degeneration with tenascin C and application for treatment","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684709779"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-12"},"publish_date":"2018-01-12","publish_status":"0","recid":"11756","relation_version_is_last":true,"title":["関節軟骨に対するテネイシンCの修復促進・変性抑制の分子機構解明と治療への応用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T01:57:49.283158+00:00"}