{"created":"2023-06-19T11:42:30.926292+00:00","id":11760,"links":{},"metadata":{"_buckets":{"deposit":"fa57e6c3-98ab-4ebc-bc86-f3102a126828"},"_deposit":{"created_by":15,"id":"11760","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"11760"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011760","sets":["631:636:1692684709779"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-12","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、アンドロゲン除去療法後の血中PSAは緩徐に低下したほうが予後良好であるという興味深い結果が報告されている。前立腺線維芽細胞由来の因子がアンドロゲン非依存性にアンドロゲン受容体(AR)を活性化することに着目し、ADT後の血中PSA動態に対する前立腺線維芽細胞の役割を検討した。アンドロゲン感受性株、正常ヒト前立腺間質細胞、初代培養したヒト前立腺癌由来線維芽細胞を用い、共培養および混合移植を行った。その結果、前立腺線維芽細胞がADT後の血中PSAを緩徐に低下させることを明らかにした。治療前の前立腺線維芽細胞からADT後の血中PSA動態を予測することができる可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"In patients with prostate cancer (PCa), serum prostate-specific antigen (PSA) is a useful marker for evaluating the effects of androgen deprivation therapy (ADT). However, the mechanism remains unknown. Tumor stroma surrounding cancer cells is enriched in fibroblasts secreting AR-stimulating factor in the context of androgen deficiency. Therefore, we investigated the role of fibroblasts in serum PSA decline after ADT. We performed co-culture and co-inoculation experiments using androgen-sensitive, androgen receptor (AR)-positive prostate epithelial cell lines (LNCaP, 22Rv1, and RWPE-1 cells), commercially available prostate stromal cells (PrSC), and primary cultures of prostate fibroblasts (pcPrFs). Our results demonstrated that fibroblasts prolong serum PSA decline after ADT. We hypothesize that pre-therapeutic characteristic of fibroblasts may reflect in serum PSA kinetics after ADT, which could be a critical biomarker for predicting CRPC.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2015年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26861266","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐々木, 豪","creatorNameLang":"ja"},{"creatorName":"ササキ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"SASAKI, Takeshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-12"}],"displaytype":"detail","filename":"39K18188.pdf","filesize":[{"value":"95.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K18188","url":"https://mie-u.repo.nii.ac.jp/record/11760/files/39K18188.pdf"},"version_id":"e407d687-dd27-44bc-94a3-27705ed555a6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"前立腺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"癌関連線維芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"PSA","subitem_subject_scheme":"Other"},{"subitem_subject":"マルチバイオマーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌間質由来マルチバイオマーカー探索による早期去勢抵抗性前立腺癌予測システムの構築","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌間質由来マルチバイオマーカー探索による早期去勢抵抗性前立腺癌予測システムの構築","subitem_title_language":"ja"},{"subitem_title":"Identification of tumor stroma-derived multi-biomarkers for predicting castration-resistant prostate cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684709779"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-12"},"publish_date":"2018-01-12","publish_status":"0","recid":"11760","relation_version_is_last":true,"title":["癌間質由来マルチバイオマーカー探索による早期去勢抵抗性前立腺癌予測システムの構築"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T01:57:58.173270+00:00"}