{"created":"2023-06-19T11:42:30.969910+00:00","id":11761,"links":{},"metadata":{"_buckets":{"deposit":"b53de965-aa70-449a-bd3c-efceba94b8ce"},"_deposit":{"created_by":15,"id":"11761","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"11761"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011761","sets":["631:636:1692684709779"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"白血球表面上に発現するLFA-1とMac-1インテグリンは血管内皮上のインテグリンリガンド（ICAM-1,2）と結合する。この結合は炎症時の白血球の血管内皮への接着と遊走を制御している。我々は①血管内皮上に存在する抗凝固因子のトロンボモジュリン（TM）が白血球のLFA-1、Mac-1インテグリンと結合すること、さらに②この結合部位はTMの細胞外ドメインのセリンスレオニンリッチドメインであることを同定した。この発見は炎症時に認められる白血球と血管内皮細胞の接着において、TMが血管内皮細胞上でICAM-1,2とともに白血球との結合に関与している可能性を示唆している。","subitem_description_type":"Abstract"},{"subitem_description":"LFA-1 and Mac-1 integrins regulate leukocyte trafficking in health and disease by binding primarily to IgSF ligand ICAM-1 and ICAM-2 on endothelial cells. Here we have shown that the anti-coagulant molecule thrombomodulin (TM), found on the surface of endothelial cells, functions as a potentially new ligand for leukocyte integrins. Furthermore, we show that the serine/threonine-rich domain of TM is required for the interaction with the LFA-1 and Mac-1 integrins to occur on PBMCs. These results demonstrate that the LFA-1 and Mac-1 integrins on leukocytes bind to TM, thereby establishing the molecular and structural basis underlying LFA-1 and Mac-1 integrin interaction with TM on endothelial cells. In fact, integrin-TM interactions might be involved in the dynamic regulation of leukocyte adhesion with endothelial cells.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2015年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26861520","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川本, 英嗣","creatorNameLang":"ja"},{"creatorName":"カワモト, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"KAWAMOTO, Eiji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-12"}],"displaytype":"detail","filename":"39K18189.pdf","filesize":[{"value":"209.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"39K18189","url":"https://mie-u.repo.nii.ac.jp/record/11761/files/39K18189.pdf"},"version_id":"de158ef4-398c-46dd-9d63-ab7402053557"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Thrombomodulin","subitem_subject_scheme":"Other"},{"subitem_subject":"LFA-1 integrin","subitem_subject_scheme":"Other"},{"subitem_subject":"Mac-1 integrin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"トロンボモジュリンと好中球の相互作用と細胞接着への影響の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"トロンボモジュリンと好中球の相互作用と細胞接着への影響の解析","subitem_title_language":"ja"},{"subitem_title":"Analysis of the interaction between neutrophil and thrombomodulin.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684709779"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-12"},"publish_date":"2018-01-12","publish_status":"0","recid":"11761","relation_version_is_last":true,"title":["トロンボモジュリンと好中球の相互作用と細胞接着への影響の解析"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-13T01:57:58.278134+00:00"}