{"created":"2023-06-19T11:42:32.266272+00:00","id":11783,"links":{},"metadata":{"_buckets":{"deposit":"8651a495-9300-4789-972c-f05f02e86dd7"},"_deposit":{"created_by":3,"id":"11783","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"11783"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00011783","sets":["813:816:1692669436025"]},"author_link":["34154","34155"],"control_number":"11783","item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-31","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"インスリン様成長因子受容体はがん細胞の増殖に重要な役目を果たしている。神経芽腫は、インスリン様成長因子に対する増殖反応性から、インスリン様成長因子を自ら産生して増殖できる群、自らは産生することはできないが、インスリン様成長因子が作用することにより増殖できる群、インスリン様成長因子には依存せずに増殖する群に分類された。さらに、神経芽腫の細胞内におけるインスリン様成長因子受容体を介した増殖シグナルの伝達には、複数の経路が用いられていた。これらの結果より、細胞内シグナル伝達を阻害する薬剤を神経芽腫患者の臨床治療に用いる場合には、増殖シグナル伝達の多様性を十分に考慮することが大切であると考えられる。","subitem_description_type":"Abstract"},{"subitem_description":"Insulin-like growth factor receptor (IGF-R) plays an important role on cancer cell proliferation. It has been shown that neuroblastoma (NB) cells can be categorized into three groups by the patterns of IGF-R pathway response. The IGF-R pathway can be activated by endogenous IGF in group 1 NB cells. Stimulation of IGF-R pathway can be induced by exogenous IGF in group 2 NB cells. Activated IGF-R pathway hardly accelerate the cell proliferation of group 3 NB cells. In addition, IGF-R growth stimulation can be mediated by several different intracellular signal transduction pathways. These results suggest that the significant heterogeneity of NB cells in IFG-R-mediated cell proliferation response should be taken enough into consideration, when any signal transduction inhibitors are used in the clinical treatment of NB patients.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2013年度～2015年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"25461590","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"駒田, 美弘","creatorNameLang":"ja"},{"creatorName":"コマダ, ヨシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Komada, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"豊田, 秀実","creatorNameLang":"ja"},{"creatorName":"トヨダ, ヒデミ","creatorNameLang":"ja-Kana"},{"creatorName":"Toyoda, Hidemi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-01-12"}],"displaytype":"detail","filename":"90K18224.pdf","filesize":[{"value":"161.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"90K18224","url":"https://mie-u.repo.nii.ac.jp/record/11783/files/90K18224.pdf"},"version_id":"e2ad3ad7-9e65-4705-89a4-9117fdd54cf2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"神経芽腫","subitem_subject_scheme":"Other"},{"subitem_subject":"インスリン様成長因子","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞内増殖シグナル","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"インスリン様成長因子が神経芽腫細胞の生存・増殖に果たす役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"インスリン様成長因子が神経芽腫細胞の生存・増殖に果たす役割の解明","subitem_title_language":"ja"},{"subitem_title":"Function of Insulin-like growth factor in neuroblastoma cell proliferation","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["1692669436025"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-01-12"},"publish_date":"2018-01-12","publish_status":"0","recid":"11783","relation_version_is_last":true,"title":["インスリン様成長因子が神経芽腫細胞の生存・増殖に果たす役割の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-11-27T01:44:52.018984+00:00"}