{"created":"2023-06-19T11:42:44.593507+00:00","id":12047,"links":{},"metadata":{"_buckets":{"deposit":"87a44589-360a-4582-89cd-adeb9c713662"},"_deposit":{"created_by":16,"id":"12047","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"12047"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012047","sets":["334:608:618:857"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03-26","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-26"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aims: The missing fundamental phenomenon (MFP) is a universal pitch perception illusion that occurs in animals and humans. In this study, we aimed to determine whether the MFP is impaired in patients with Alzheimer’s disease (AD) using an auditory pitch perception experiment. We further examined anatomical correlates of the MFP in patients with AD by measuring gray matter volume (GMV) on magnetic resonance images via voxel-based morphometric analysis. Methods: We prospectively enrolled 29 patients with AD and 20 healthy older adults. Auditory stimuli included 12 melodies of Japanese nursery songs that were expected to be familiar to participants. We constructed the melodies using pure and missing fundamental tones (MFTs). Results: Patients with AD exhibited significantly poorer performance on the MFT task than healthy controls. MFT scores were positively correlated with GMV in the bilateral insula and temporal poles, left inferior frontal gyrus, right entorhinal cortex, and right cerebellum. Conclusions: These results suggest that impairments in the MFP represent a manifestation of the degeneration of auditory-related brain regions in AD. Further studies are required to more fully elucidate the neural mechanisms underlying auditory impairments in patients with AD and related dementia disorders.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文 / Department of Dementia Prevention and Therapeutics, Graduate School of Medicine,Mie University,Mie,Japan","subitem_description_type":"Other"},{"subitem_description":"31p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第1877号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1159/000486331","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Dementia and Geriatric Cognitive Disorders Extra. 2018 Jan-Apr; 8(1) : 23-32, ISSN:1664-5464 に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAlternatives":[{"creatorAlternative":"田部井, 真貴子","creatorAlternativeLang":"ja"},{"creatorAlternative":"タベイ, マキコ","creatorAlternativeLang":"ja-Kana"}],"creatorNames":[{"creatorName":"Abe, Makiko","creatorNameLang":"en"},{"creatorName":"アベ, マキコ","creatorNameLang":"ja-Kana"},{"creatorName":"阿部, 真貴子","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-17"}],"displaytype":"detail","filename":"2017DM020.pdf","filesize":[{"value":"609.4 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2017DM020","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/12047/files/2017DM020.pdf"},"version_id":"d5f5f4ac-65d2-48ee-9c32-87aa39d40db2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alzheimer’s disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dementia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pitch perception","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Missing fundamental phenomenon","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Magnetic","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Impairment of the missing fundamental phenomenon in individuals with Alzheimer's disease: a neuropsychological and voxel-based morphometric study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impairment of the missing fundamental phenomenon in individuals with Alzheimer's disease: a neuropsychological and voxel-based morphometric study","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["857"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-07-17"},"publish_date":"2018-07-17","publish_status":"0","recid":"12047","relation_version_is_last":true,"title":["Impairment of the missing fundamental phenomenon in individuals with Alzheimer's disease: a neuropsychological and voxel-based morphometric study"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-11-02T00:18:40.349963+00:00"}