{"created":"2023-06-19T11:42:46.456742+00:00","id":12085,"links":{},"metadata":{"_buckets":{"deposit":"37bc262e-0cc1-42af-9665-bdb5561a59d2"},"_deposit":{"created_by":16,"id":"12085","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"12085"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012085","sets":["334:608:618:857"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-03-26","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-03-26"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: This study aims to investigate the association between the presence and frequency of cortical lesions (CLs), and the clinical and psychological features of multiple sclerosis (MS).Methods: A total of 19 patients with MS were examined using double inversion recovery (DIR) sequences with 3T magnetic resonance imaging (MRI) and classified into two groups: CL and non-CL. In-house software was used to quantitatively determine the atrophy of each brain region. Activities of daily living (ADL) were estimated using the Kurtzke Expanded Disability Status Scale (EDSS). Cognitive function was assessed using the following tests: Mini-Mental State Examination (MMSE), Trail Making Test (TMT), and Paced Auditory Serial Addition Task (PASAT). Z-scores were used to assess significant differences in the neuropsychological test outcomes between the groups.Results: Six of 19 patients had subcortical and deep WM lesions (non-CL group; diagnosed with relapsing-remitting MS). Thirteen of 19 patients had both subcortical and cortical lesions (CL group; 9-relapsing-remitting MS; 4-primary/secondary progressive MS). There were no significant differences in age, education, and disease duration, but EDSS scores were significantly higher in the CL group compared to the non-CL group. There were no significant differences in gray and white matter volume between the CL and the non-CL groups, but the white matter lesion volume was significantly higher in the CL group compared to the non-CL group. Neuropsychological tests showed significant performance worsening in the CL group as compared to the standard values for healthy individuals in their age group, especially in the TMT data.Conclusions: Progressive MS, which was associated with decreased physical functioning, ADL, and cognitive impairment, was found in patients in the CL group.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文 / Department of Dementia Prevention and Therapeutics, Mie University","subitem_description_type":"Other"},{"subitem_description":"30p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第1895号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/brb3.934","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Brain Behav. 2018 Feb 14;8(3):e00934, ISSN:2162-3279 に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Matsushita, Futoshi","creatorNameLang":"en"},{"creatorName":"マツシタ, フトシ","creatorNameLang":"ja-Kana"},{"creatorName":"松下, 太","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-07-23"}],"displaytype":"detail","filename":"2017DM038.pdf","filesize":[{"value":"810.4 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2017DM038","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/12085/files/2017DM038.pdf"},"version_id":"46f0df32-bde6-443a-9064-6a87e39fe6a1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cognitive impairment","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cortical lesions","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"magnetic resonance imaging","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"multiple sclerosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neuropsychological tests","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["857"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2018-07-23"},"publish_date":"2018-07-23","publish_status":"0","recid":"12085","relation_version_is_last":true,"title":["Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-11-02T00:19:12.493422+00:00"}