{"created":"2023-06-19T11:42:57.366803+00:00","id":12299,"links":{},"metadata":{"_buckets":{"deposit":"dc3fea6e-1ba5-4072-bd60-a16ed6847a5c"},"_deposit":{"created_by":16,"id":"12299","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"12299"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012299","sets":["334:608:618:915"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09-19","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-09-19"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Social anxiety disorder (SAD) is characterized by strong fear and anxiety during social interactions. Although ventrolateral prefrontal cortex (VLPFC) activity in response to emotional stimuli is related to pathological anxiety, little is known about the relationship between VLPFC activity and social anxiety. This study aimed to investigate whether VLPFC activity was involved in SAD and whether VLPFC activity was related to the level of social anxiety. Twenty-four drug-naïve patients with SAD and 35 healthy controls underwent near-infrared spectroscopy (NIRS) scanning while performing a verbal fluency task (VFT). Results indicated that, compared to the healthy controls, the SAD patients exhibited smaller changes of oxygenated hemoglobin (oxy-Hb) concentrations in the VLPFC during the VFT. Furthermore, the right VLPFC activation was negatively correlated with social avoidance. In contrast to the latter, the healthy controls exhibited a positive correlation between changes of oxy-Hb concentrations in the bilateral VLPFC and social fear. Our findings provide evidence for VLPFC dysfunction in SAD, and indicate that the VLPFC dysfunction may contribute to the difference between normal and abnormal social anxiety.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文 /  Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Mie, Japan.","subitem_description_type":"Other"},{"subitem_description":"7p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙医学第1021号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.nicl.2015.05.011","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Neuroimage Clin. 2015 May 28;8:455-461 に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAlternatives":[{"creatorAlternative":"葛島, 知加","creatorAlternativeLang":"ja"},{"creatorAlternative":"クズシマ, チカ","creatorAlternativeLang":"ja-Kana"}],"creatorNames":[{"creatorName":"Yokoyama, Chika","creatorNameLang":"en"},{"creatorName":"ヨコヤマ, チカ","creatorNameLang":"ja-Kana"},{"creatorName":"横山, 知加","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-02-19"}],"displaytype":"detail","filename":"2018DM0910.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2018DM0910.pdf","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/12299/files/2018DM0910.pdf"},"version_id":"2382bfd0-c9de-4e74-bd7c-2877251c141a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Social anxiety disorder","subitem_subject_scheme":"Other"},{"subitem_subject":"Ventrolateral prefrontal cortex","subitem_subject_scheme":"Other"},{"subitem_subject":"Emotion","subitem_subject_scheme":"Other"},{"subitem_subject":"Near-infrared spectroscopy (NIRS)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Dysfunction of ventrolateral prefrontal cortex underlying social anxiety disorder: A multi-channel NIRS study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Dysfunction of ventrolateral prefrontal cortex underlying social anxiety disorder: A multi-channel NIRS study","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["915"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-02-19"},"publish_date":"2019-02-19","publish_status":"0","recid":"12299","relation_version_is_last":true,"title":["Dysfunction of ventrolateral prefrontal cortex underlying social anxiety disorder: A multi-channel NIRS study"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-10-31T06:01:39.665610+00:00"}