{"created":"2023-06-19T11:42:58.837566+00:00","id":12333,"links":{},"metadata":{"_buckets":{"deposit":"f1ae8ae3-59d2-4a67-a7b0-53553edf0bb9"},"_deposit":{"created_by":16,"id":"12333","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"12333"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012333","sets":["334:608:618:915"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-12-19","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2018-12-19"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学）"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Suppressor of cytokine signaling 1 (SOCS1) is a negative regulator of JAK/STAT signaling and is induced by mycobacterial infection. To understand the major function of SOCS1 during infection, we established a novel system in which recombinant Bacillus Calmette-Guérin expressed dominant-negative SOCS1 (rBCG-SOCS1DN) because it would not affect the function of SOCS1 in uninfected cells. When C57BL/6 mice and Rag1-/- 33 mice were intratracheally inoculated with rBCG-SOCS1DN, the amount of rBCG-SOCS1DN in the lungs was significantly reduced compared to the amounts in the lungs of mice inoculated with a vector control counterpart and wild-type BCG. However, these significant differences were not observed in Nos2-/- mice and Rag1-/-Nos2-/- 37 double-knockout mice. These findings demonstrated that SOCS1 inhibits NO production to establish mycobacterial infection and the rBCG-SOCS1DN has the potential to be a powerful tool for studying the primary function of SOCS1 in mycobacterial infection.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Department of Molecular and Experimental Medicine","subitem_description_type":"Other"},{"subitem_description":"40P","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第1924号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1128/IAI.00376-18","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Infection and Immunity 2018 Oct 25;86(11)に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Soma, Shogo","creatorNameLang":"en"},{"creatorName":"ソウマ, ショウゴ","creatorNameLang":"ja-Kana"},{"creatorName":"相馬, 祥吾","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-04-09"}],"displaytype":"detail","filename":"2018DM1204.pdf","filesize":[{"value":"3.6 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"本文","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/12333/files/2018DM1204.pdf"},"version_id":"423f0bb0-0ece-4a52-9a23-3b9304db4aff"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Primary role of suppressor of cytokine signaling 1 in Mycobacterium bovis BCG infection","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Primary role of suppressor of cytokine signaling 1 in Mycobacterium bovis BCG infection","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["915"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-04-09"},"publish_date":"2019-04-09","publish_status":"0","recid":"12333","relation_version_is_last":true,"title":["Primary role of suppressor of cytokine signaling 1 in Mycobacterium bovis BCG infection"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-10-31T06:01:58.679551+00:00"}