{"created":"2023-06-19T11:43:02.296161+00:00","id":12416,"links":{},"metadata":{"_buckets":{"deposit":"56efe959-a8a8-4633-8719-61ab4ef87dc1"},"_deposit":{"created_by":15,"id":"12416","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"12416"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012416","sets":["334:627:1692670416720"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-06","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"サルコペニアは治療方法だけでなく病態機序も不明な点が多い.本研究は肥満型サルコペニアに注目し,まずob/obマウスを検討し,有意な体重増加に反して有意に低い筋湿重量を示した.骨格筋MDAは有意に高く,肥満では骨格筋が慢性的な酸化ストレス障害に曝されている可能性があった.また血流低下モデルは骨格筋再生能が低く,閉塞性動脈硬化症などを合併するとさらに骨格筋減少が進行する可能性があった.さらにC2C12の酸化ストレス障害に対して,edaravoneによる抗酸化治療を検討し,有意な生存率改善,MDA低下,TNF-α抑制を示し,抗酸化治療の骨格筋の酸化ストレス障害に対する有用性を示した. ","subitem_description_type":"Abstract"},{"subitem_description":"We have little knowledge about pathology and treatment for sarcopenia. The aims of this study were to evaluate the skeletal muscles in ob/ob mice, and to examine effect of antioxidant to skeletal muscles on C2C12. In ob/ob, muscle weight were significantly less heavy than that in control, whilst ob/ob significantly heavily weighed than control. Likewise, level of MDA were higher in the muscles of ob/ob than that of control. Additionally, skeletal muscles during regeneration were weakly immunolabeled for myoD in obese mice compared to control mice. Furthermore, protective effect of edaravone (100 µM) were analyzed on C2C12 myoblast under oxidative stress using 250 µM H202 with results in significant cell viability and inhibition of level of MDA and expression of TNF-alfa. This study showed that chronic oxidative stress involved in pathophysiology of sarcopenia in obesity and that administration of antioxidant effectively treated oxidative stress of skeletal muscles. ","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2016年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26462238","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"辻井, 雅也","creatorNameLang":"ja"},{"creatorName":"TUJII, Masaya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"須藤, 啓広","creatorNameLang":"ja"},{"creatorName":"SUDO, Akihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"長谷川, 正裕","creatorNameLang":"ja"},{"creatorName":"HASEGAWA, Masahiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-08"}],"displaytype":"detail","filename":"2018RP0022.pdf","filesize":[{"value":"343.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018RP0022","url":"https://mie-u.repo.nii.ac.jp/record/12416/files/2018RP0022.pdf"},"version_id":"410249b4-4c22-46f0-af35-9b96a800ed4e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨格筋","subitem_subject_scheme":"Other"},{"subitem_subject":"肥満","subitem_subject_scheme":"Other"},{"subitem_subject":"サルコペニア","subitem_subject_scheme":"Other"},{"subitem_subject":"抗酸化治療","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"サルコペニア治療への挑戦－骨格筋虚血/再潅流障害の病態とオルガネラが果たす役割－","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"サルコペニア治療への挑戦－骨格筋虚血/再潅流障害の病態とオルガネラが果たす役割－","subitem_title_language":"ja"},{"subitem_title":"Challenges to new treatment for sarcopenia","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670416720"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"12416","relation_version_is_last":true,"title":["サルコペニア治療への挑戦－骨格筋虚血/再潅流障害の病態とオルガネラが果たす役割－"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-08T04:03:42.281387+00:00"}