{"created":"2023-06-19T11:43:02.381156+00:00","id":12418,"links":{},"metadata":{"_buckets":{"deposit":"25b83940-cd93-4417-ab20-f0716d19bb2e"},"_deposit":{"created_by":15,"id":"12418","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"12418"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012418","sets":["334:627:1692670416720"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-23","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、胎生期に発生した成熟血液細胞が、成体骨髄の造血幹細胞へ依存せず、生涯にわたり、末梢組織に存在し続けることが示されている。本研究課題では、これらの成体造血幹細胞非依存的な細胞系譜の発生学的起源を探るとともに、その起源の違いによる機能差異の可能性について精査した。その結果、造血幹細胞非依存的マクロファージについては、卵黄嚢の起源を示唆した。また卵黄嚢に由来するNK細胞の存在を明らかとし、成体由来NK細胞と機能差異を見出した。 ","subitem_description_type":"Abstract"},{"subitem_description":"In recent years, it has been shown that some mature blood cells originated from embryonic stages persist in adult bodies independently from hematopoietic stem cells (HSC). In this study, we searched the origins of these HSC-independent cell lineages and examined the functional differences between embryo-derived cells and HSC-derived cells. Our study indicated the origin of some macrophages and NK cells in the yolk sac. In addition, we observed a functional differences between yolk sac-derived and adult HSC-derived NK cell lineages.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2016年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26461442","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山根, 利之","creatorNameLang":"ja"},{"creatorName":"YAMANE, Toshiyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山崎, 英俊","creatorNameLang":"ja"},{"creatorName":"YAMAZAKI, Hidetoshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-08"}],"displaytype":"detail","filename":"2018RP0024.pdf","filesize":[{"value":"255.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018RP0024","url":"https://mie-u.repo.nii.ac.jp/record/12418/files/2018RP0024.pdf"},"version_id":"4737ae1a-8cb3-41fc-88bf-fd4df4ef12ae"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"造血発生","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞分化","subitem_subject_scheme":"Other"},{"subitem_subject":"造血幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"発生","subitem_subject_scheme":"Other"},{"subitem_subject":"卵黄嚢","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"NK細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"B-1 B細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"成体の血液細胞系譜の起源の多様性と機能との関連性についての幹細胞学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"成体の血液細胞系譜の起源の多様性と機能との関連性についての幹細胞学的研究","subitem_title_language":"ja"},{"subitem_title":"Multiple developmental origins of adult blood cell lineages and its relevance to functions","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670416720"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"12418","relation_version_is_last":true,"title":["成体の血液細胞系譜の起源の多様性と機能との関連性についての幹細胞学的研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-08T04:03:46.970300+00:00"}