{"created":"2023-06-19T11:43:02.466683+00:00","id":12420,"links":{},"metadata":{"_buckets":{"deposit":"2046a8f6-7548-4629-8470-00aa4fbc39d3"},"_deposit":{"created_by":15,"id":"12420","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"12420"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012420","sets":["334:627:1692670416720"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-29","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"同種造血幹細胞移植後に起こる移植片対宿主病（GVHD）は、移植成功への障壁となる合併症の一つである。慢性GVHDは組織線維化病態を伴うのが特徴であるが、発症メカニズムは不明な点が多く、治療法も確立していない。本研究では、組織線維化を制御するテネイシン-C（TN-C）の慢性GVHD発症における役割を、マウスモデル、臨床検体を用いて検討した。マウス移植モデルでは、TN-Cを産生する細胞はレシピエント由来であることが明らかとなり、TN-Cを発現しないノックアウトマウスでは、GVHDが増悪する傾向が認められた。現在、移植患者血漿中TN-Cと慢性GVHD発症との関係を検討中である。","subitem_description_type":"Abstract"},{"subitem_description":"Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative therapy for refractory hematological malignancies. Complication occured after allo-HSCT such as graft-vs-host disease (GVHD) is an obstacle for successful allo-HSCT. Pathophysioligy of chronic GVHD (cGVHD) that features tissue fibrosis is still unclear and standard therpy for cGVHD has not been established yet. Tenascin-C (TN-C) is involved in tissue fibrosis and its role in cGVHD pathophysiolgy is unknown. In this study, we investigated the role of TN-C in cGVHD using mouse model and clinical samples. Mouse models demonstrated that TN-C was produced by recipient-origin cells and there was a tendency that GVHD was exacerbated in TN-C-deficient mice. Analysis of relation between TN-C level in patient's plasma and cGVHD onset is underway.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2016年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26461441","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"俵, 功","creatorNameLang":"ja"},{"creatorName":"TAWARA, Isao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"吉田, 恭子(今中 恭子)","creatorNameLang":"ja"},{"creatorName":"YOSHIDA, Imanaka-kyoko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-08"}],"displaytype":"detail","filename":"2018RP0026.pdf","filesize":[{"value":"90.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018RP0026","url":"https://mie-u.repo.nii.ac.jp/record/12420/files/2018RP0026.pdf"},"version_id":"325c1495-1bdc-45d1-aba2-90d77303b4ca"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GVHD","subitem_subject_scheme":"Other"},{"subitem_subject":"テネイシン-C","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"慢性GVHD組織線維化病態におけるテネイシン‐Cの役割の解明と標的治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性GVHD組織線維化病態におけるテネイシン‐Cの役割の解明と標的治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Role of tenascin-C in development of fibrosis in chronic GVHD tissue and establishment of its targetted therapy","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670416720"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"12420","relation_version_is_last":true,"title":["慢性GVHD組織線維化病態におけるテネイシン‐Cの役割の解明と標的治療法の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-08T04:03:51.414049+00:00"}