{"created":"2023-06-19T11:43:02.815146+00:00","id":12428,"links":{},"metadata":{"_buckets":{"deposit":"5f4636d6-177f-4939-9d39-0ec7a014dc22"},"_deposit":{"created_by":15,"id":"12428","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"12428"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012428","sets":["334:627:1692670416720"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-08-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"パラインフルエンザウイルスのエンべロープ蛋白HNの頭部領域は細胞膜上の受容体に結合すると構造変化を起こし,それまで隠されていたストーク領域がウイルス特異的にエンべロープ蛋白Fの頭部領域と相互作用して活性化することで,Fが膜融合の誘導そして細胞へのウイルス侵入を媒介する。このHN-F相互作用における特異性は異なるウイルス間でのHNストーク領域とF頭部領域の一時構造の相同性によって一義的に決まるものとされてきた。しかし本研究により,HN頭部領域およびFストーク領域がそれぞれHNストーク領域およびF頭部領域の立体構造に影響をおよぼすことでHN-F相互作用の特異性を修飾していることが明らかになった。 ","subitem_description_type":"Abstract"},{"subitem_description":"It is widely appreciated that during the course of membrane fusion by parainfluenza viruses, the head domain of the viral envelope protein HN (hemagglutinin-neuraminidase) undergoes a structural transition after its binding to the receptors on the cell surface, that exposes otherwise hidden stalk domain of the HN. The exposed HN stalk domain then interacts with the head domain of another viral  envelope protein F (fusion) in a virus-specific manner, which enables the F to undergo a series of structural changes that lead to merger of viral and cellular membranes. Such specificity is believed tp be defined by the similarity in the primary structures of the HN stalk domain and the F head domain between different viruses. However, our present study revealed that the HN head domain and F stalk domain can modulate the specificity by affecting tertiary and/or quaternary structures of the HN stalk domain and the F head domain, respectively.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2016年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26460552","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鶴留, 雅人","creatorNameLang":"ja"},{"creatorName":"TSURUDOME, Masato","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-08"}],"displaytype":"detail","filename":"2018RP0037.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018RP0037","url":"https://mie-u.repo.nii.ac.jp/record/12428/files/2018RP0037.pdf"},"version_id":"5896e516-5119-4b96-8cac-0c158ff6fc54"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"パラインフルエンザウイルス","subitem_subject_scheme":"Other"},{"subitem_subject":"HN蛋白","subitem_subject_scheme":"Other"},{"subitem_subject":"F蛋白","subitem_subject_scheme":"Other"},{"subitem_subject":"分子間相互作用","subitem_subject_scheme":"Other"},{"subitem_subject":"膜融合","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞融合","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"パラミクソウイルスの膜融合における機能的および物理的HN-F相互作用の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"パラミクソウイルスの膜融合における機能的および物理的HN-F相互作用の解析","subitem_title_language":"ja"},{"subitem_title":"Analysis of functional and physical HN-F interaction in the course of membrane fusion by paramyxoviruses","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670416720"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"12428","relation_version_is_last":true,"title":["パラミクソウイルスの膜融合における機能的および物理的HN-F相互作用の解析"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-08T04:04:09.746597+00:00"}