{"created":"2023-06-19T11:43:02.905505+00:00","id":12430,"links":{},"metadata":{"_buckets":{"deposit":"2ba33912-7f65-4509-af7c-c75356f601f0"},"_deposit":{"created_by":15,"id":"12430","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"12430"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012430","sets":["334:627:1692670416720"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-03","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"網羅的microRNA(miRNA)解析を胃癌腫瘍組織、正常組織よりmicroRNAs発現を解析した。結果、上皮間葉移行に関わるmiRNAが胃癌の遠隔転移と相関していた。血清miR-203を同定し、これがステージⅠ-Ⅲの胃癌患者よりも、ステージⅣ胃癌患者で有意に低いことを示し、この低発現は胃癌患者の予後不良の独立した予測マーカーであることを明らかにした。胃癌組織におけるMTA-1発現は腹膜播種予測因子として有用であること、さらに胃癌組織ANGPTL2高発現、並びに血清におけるANGPTL2濃度上昇は、腹膜播種と相関し予後不良群の鑑別に有用である可能性を示した。","subitem_description_type":"Abstract"},{"subitem_description":"Comprehensive microRNA (miRNA) analysis was analyzed for expression of microRNAs from gastric cancer tumor tissue and normal tissue. MiRNAs involved in epithelial mesenchymal transition correlated with distant metastasis of gastric cancer. Serum miR-203 was identified and it was shown that it was significantly lower in stage TV gastric cancer patients than in stage Ⅰ - Ⅲ gastric cancer patients, and this low expression was found to be an independent predictive marker of poor prognosis in gastric cancer patients. The fact that MTA-1 expression in gastric cancer tissues is useful as a peritoneal dissemination predictor, and that the high expression of gastric cancer tissue ANGPTL 2 and the increase in ANGPTL 2 concentration in serum correlate with peritoneal dissemination and are useful for differentiation of poor prognosis group Indicated.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度~2016年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26461976","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者(ヨミ)","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ(三重大)","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"沖上, 正人","creatorNameLang":"ja"},{"creatorName":"OKIGAMI, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"TOIYAMA, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"KUSUNOKI, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"毛利, 靖彦","creatorNameLang":"ja"},{"creatorName":"MOHRI, Yasuhiko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-08"}],"displaytype":"detail","filename":"2018RP0039.pdf","filesize":[{"value":"168.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018RP0039","url":"https://mie-u.repo.nii.ac.jp/record/12430/files/2018RP0039.pdf"},"version_id":"6e182339-d4c2-467c-869e-710a84b8d831"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胃癌","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"腹膜播種","subitem_subject_scheme":"Other"},{"subitem_subject":"遠隔転移","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胃癌腹膜播種を規定するmicroRNAの網羅的解析と治療戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃癌腹膜播種を規定するmicroRNAの網羅的解析と治療戦略","subitem_title_language":"ja"},{"subitem_title":"Comprehensive analysis and treatment strategy of MicroRNA that regulates peritoneal metastasis of gastric cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670416720"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"12430","relation_version_is_last":true,"title":["胃癌腹膜播種を規定するmicroRNAの網羅的解析と治療戦略"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-08T04:04:14.678392+00:00"}