{"created":"2023-06-19T11:43:02.950596+00:00","id":12431,"links":{},"metadata":{"_buckets":{"deposit":"5ff4aff7-cddc-44ae-814d-2c368ec5ff30"},"_deposit":{"created_by":15,"id":"12431","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"12431"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012431","sets":["334:627:1692670416720"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-06-07","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腹膜播種に関与するlncRNAのminiRNAが腹膜播種診断血清マーカーとして有用かどうかをlncRNAの発現とその臨床病理学的因子や異時性再発の有無(時期)と再発臓器、予後との相関を解析し、2つのlncRNAを同定した。1つはMALAT 1、もう1つはHOTAIRである。HOTAIRは組織増殖、細胞浸潤、アノイキスと関与し、HOTAIR siRNAにてトランスフェクトさせた胃癌細胞株では腹膜播種出現が有意に抑制された。血清angiopoietin-like protein 2、mir-203が遠隔転移陽性胃癌あるいは術後再発症例で有意に高値を示す血清バイオマーカーであることが検証できた。","subitem_description_type":"Abstract"},{"subitem_description":"The prognosis of gastric cancer (GC) patients with peritoneal dissemination remains poor, and a better understanding of the underlying mechanisms is critical for the development of new treatments that will improve survival in these patients. This study aimed to clarify the clinical and biological role of two key metastasis-associated long non-coding RNAs (IncRNAs) in GC. We analyzed the expression levels of two IncRNAs in gastric tissues. Expression of 2 IncRNAs was significantly higher in cancerous tissues than in corresponding normal mucosa, and higher expression of these IncRNAs significantly correlated with peritoneal metastasis in GC patients. Our data provide novel evidence for the biological and clinical significance of HOTAIR expression as a potential biomarker for identifying patients with peritoneal metastasis, and as a novel therapeutic target in patients with gastric neoplasia.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2016年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26461975","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"毛利, 靖彦","creatorNameLang":"ja"},{"creatorName":"MOHRI, Yasuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"TOIYAMA, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"田中, 光司","creatorNameLang":"ja"},{"creatorName":"TANAKA, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"KUSUNOKI, Masato","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-08"}],"displaytype":"detail","filename":"2018RP0040.pdf","filesize":[{"value":"624.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018RP0040","url":"https://mie-u.repo.nii.ac.jp/record/12431/files/2018RP0040.pdf"},"version_id":"cddc0338-afdd-4a94-a496-0291651c74e9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胃癌","subitem_subject_scheme":"Other"},{"subitem_subject":"腹膜播種","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胃癌腹膜播種に関与するlncRNAの解明―新規診断・治療法への応用を目指して―","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃癌腹膜播種に関与するlncRNAの解明―新規診断・治療法への応用を目指して―","subitem_title_language":"ja"},{"subitem_title":"Identification of biomarker for peritoneal dissemination from gastric cancer: analysis of Inc RNA","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670416720"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"12431","relation_version_is_last":true,"title":["胃癌腹膜播種に関与するlncRNAの解明―新規診断・治療法への応用を目指して―"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-08T04:04:16.678728+00:00"}