{"created":"2023-06-19T11:43:02.995853+00:00","id":12432,"links":{},"metadata":{"_buckets":{"deposit":"ded9b587-16d2-462f-a3ed-42788b25dd19"},"_deposit":{"created_by":15,"id":"12432","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"12432"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012432","sets":["334:627:1692670416720"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"造血細胞移植後の予後を左右する慢性GVHDの治療法はいまだ確立されていない。我々は以前に慢性GVHDでは主に抗炎症性単球がIL-10を産生し、障害された標的臓器の修復に関与していることを証明した。マクロファージには炎症型M1タイプと抗炎症型のM2タイプが存在する。このM2マクロファージを用いてGVHDの新規治療法の開発を行った。マウス骨髄細胞よりGM-CSFおよびM-CSFのサイトカインで培養することでそれぞれM1およびM2の２種類のマクロファージの誘導を行った。マウスGVHDモデルにおいてM2マクロファージは致死的GVHDを抑制し、生存率向上させた。今後の臨床応用が期待される。 ","subitem_description_type":"Abstract"},{"subitem_description":"Treatment of chronic GVHD, which influences prognosis after hematopoietic cell transplantation, has not yet been established. We have previously demonstrated that anti-inflammatory monocytes produce IL-10 in chronic GVHD and are involved in the repair of damaged target organs. There are inflammatory M1 type and anti-inflammatory type M2 type in macrophages. Using this M2 macrophage, a novel treatment for GVHD has developed. Two types of macrophages M1 and M2 were induced by culturing them with cytokines of GM-CSF and M-CSF from mouse bone marrow cells. In murine GVHD model, M2 macrophages reduced lethal GVHD and improved survival rate. Future clinical application has been expected.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2016年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26461443","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平山, 雅浩","creatorNameLang":"ja"},{"creatorName":"HIRAYAMA, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岩本, 彰太郎","creatorNameLang":"ja"},{"creatorName":"IWAMOTO, Shotaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"豊田, 秀実","creatorNameLang":"ja"},{"creatorName":"TOYODA, Hidemi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-08"}],"displaytype":"detail","filename":"2018RP0041.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018RP0041","url":"https://mie-u.repo.nii.ac.jp/record/12432/files/2018RP0041.pdf"},"version_id":"73b26203-b3ed-4ee7-ba39-6fffc9e87129"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"移植片対宿主病","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"単球","subitem_subject_scheme":"Other"},{"subitem_subject":"造血細胞移植","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"M2マクロファージを用いた移植後慢性GVHDに対する新規細胞治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"M2マクロファージを用いた移植後慢性GVHDに対する新規細胞治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Development of novel treatment for GVHD following hematopoietic cell transplantation using M2 macrophage","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670416720"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"12432","relation_version_is_last":true,"title":["M2マクロファージを用いた移植後慢性GVHDに対する新規細胞治療法の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-08T04:04:18.541770+00:00"}