{"created":"2023-06-19T11:43:03.131767+00:00","id":12435,"links":{},"metadata":{"_buckets":{"deposit":"1fe785b7-5a92-4d3e-b388-145c9fdac1af"},"_deposit":{"created_by":15,"id":"12435","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"12435"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012435","sets":["631:636:1692684729425"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-23","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"マクロライドの少量長期投与はびまん性汎細気管支炎や慢性気管支炎、慢性副鼻腔炎に効果的であるが、その機序はまだ十分解明されていない。MKP-1は最近ステロイドなどの抗炎症薬の効果にかかわっていることが報告されているが、ムチン遺伝子発現に対しては不明である。今回我々はクラリスロマイシンにてMKP-1発現が亢進することを明らかにした。またクラリスロマイシンはp38シグナルを介してMUC5AC遺伝子発現を抑制することも示した。今回の結果はマクロライドの効果におけるMKP-1の新しい役割を明らかにムチン過分泌に対する創薬に貢献するものと考える。","subitem_description_type":"Abstract"},{"subitem_description":"Low-dose, long-term macrolide therapy is effective in patients with chronic airway diseases such as diffuse panbronchitis, chronic bronchitis, and chronic sinusitis. However, the mechanism underlying this clinical efficacy remains unclear. It was recently reported that MKP-1 appears to mediate the effects of several anti-inflammatory drugs, including glucocorticoids, but the role of MKP-1 on mucin gene expression in the presence of macrolide remains unknown in human airways. Here, we show that MKP-1protein is induced by clarithromycin, and that clarithromycin suppresses TNF-α-induced MUC5AC mucin gene expression in a p38 MAPK-dependent manner in human airway epithelial cells, NCI-H292 cells. Our study thus provides new insights into the role of MKP-1 on the effect of macrolides, and may help in the development of new therapeutic strategies against mucin overproduction. ","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2016年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26462578","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石永, 一","creatorNameLang":"ja"},{"creatorName":"ISHINAGA, Hajime","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-08"}],"displaytype":"detail","filename":"2018RP0053.pdf","filesize":[{"value":"169.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018RP0053","url":"https://mie-u.repo.nii.ac.jp/record/12435/files/2018RP0053.pdf"},"version_id":"1c6be7af-d036-4bf5-87e4-4e2bed42b0c7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"MUC5AC","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロライド","subitem_subject_scheme":"Other"},{"subitem_subject":"MKP-1","subitem_subject_scheme":"Other"},{"subitem_subject":"ｐ３８","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"マクロライドの作用機序の解明と新しい併用療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"マクロライドの作用機序の解明と新しい併用療法の開発","subitem_title_language":"ja"},{"subitem_title":"Investigation for the mechanism of macrolide and development for combination therapy with macrolide","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684729425"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"12435","relation_version_is_last":true,"title":["マクロライドの作用機序の解明と新しい併用療法の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:10:19.075300+00:00"}