{"created":"2023-06-19T11:43:03.222147+00:00","id":12437,"links":{},"metadata":{"_buckets":{"deposit":"da14b2df-2ea5-4f2a-b310-aba4588f4a58"},"_deposit":{"created_by":15,"id":"12437","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"12437"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012437","sets":["631:636:1692684729425"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-15","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"DSS誘発潰瘍性大腸炎モデルラットにおいて、免疫抑制薬であるタクロリムスの経口吸収が増加することが明らかとなり、その機構の一部に小腸粘膜のP-糖タンパク質発現量の減少が関与する可能性が示唆された。さらに、潰瘍性大腸炎モデルラットの小腸においてマイクロRNAの発現変動が認められた。miRNAは小腸上皮細胞に発現する薬物動態制御タンパク質の発現・機能を制御することから、タクロリムスの体内動態変動の個体内・個体間変動の要因となる可能性が示唆された。 ","subitem_description_type":"Abstract"},{"subitem_description":"Our study demonstrates that oral absorption of tacrolimus (an immunosuppressant) was increased in dextran sodium sulfate (DSS) -induced ulcerative colitis rats, and this is attributable to decreased intestinal P-glycoprotein. In addition, the altered expression of miRNAs in the small intestine were observed in DSS-induced ulcerative colitis rats. MiRNAs regulate the expression and function of proteins regulating pharmacokinetics in intestinal epithelial cells. Therefore, miRNAs could be significant factors affecting inter- and intra- individual variations in the pharmacokinetics of tacrolimus.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2016年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26460195","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池村, 健治","creatorNameLang":"ja"},{"creatorName":"IKEMURA, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"奥田, 真弘","creatorNameLang":"ja"},{"creatorName":"OKUDA, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岩本, 卓也","creatorNameLang":"ja"},{"creatorName":"IWAMOTO, Takuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"荒木, 俊光","creatorNameLang":"ja"},{"creatorName":"ARAKI, Toshimitsu","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-08"}],"displaytype":"detail","filename":"2018RP0055.pdf","filesize":[{"value":"744.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018RP0055","url":"https://mie-u.repo.nii.ac.jp/record/12437/files/2018RP0055.pdf"},"version_id":"03f87c9f-51d4-4171-8324-9baf60d8d1b0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"マイクロRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"潰瘍性大腸炎","subitem_subject_scheme":"Other"},{"subitem_subject":"P-糖タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"タクロリムス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症性腸疾患時のタクロリムスの薬物体内動態と薬効制御におけるマイクロRNAの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症性腸疾患時のタクロリムスの薬物体内動態と薬効制御におけるマイクロRNAの役割","subitem_title_language":"ja"},{"subitem_title":"Role of microRNA on the pharmacokinetics and pharmacodynamics of tacrolimus in inflammatory bowel disease","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684729425"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"12437","relation_version_is_last":true,"title":["炎症性腸疾患時のタクロリムスの薬物体内動態と薬効制御におけるマイクロRNAの役割"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:10:23.769316+00:00"}