{"created":"2023-06-19T11:43:03.267015+00:00","id":12438,"links":{},"metadata":{"_buckets":{"deposit":"8a14d5da-b9d3-4a18-87fe-4874fc507ee3"},"_deposit":{"created_by":15,"id":"12438","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"12438"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012438","sets":["631:636:1692684729425"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-11","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腎移植術後早期にCYP3A5の遺伝子型が欠損型の患者では、免疫抑制薬であるタクロリムスの血中濃度が一過性に上昇することが明らかとなり、その要因としてインターロイキン-6を介したCYP3A4発現量の低下が関与している可能性が示唆された。一方で、臓器移植患者における免疫抑制薬の体内動態の個人差に有意な影響を及ぼすマイクロRNA（miRNA）を同定することができず、miRNAを指標として個別化薬物療法の実現に向け、今後さらなる検討が必要である。","subitem_description_type":"Abstract"},{"subitem_description":"Our study demonstrates that blood concentrations of tacrolimus (an immunosuppressant) are transiently elevated in patients with poor metabolizer of CYP3A5 in the early postoperative period of renal transplantation, and this is attributable to decreased CYP3A4 level via interleukin-6. On the other hand, microRNAs (miRNAs) affecting individual variations in the pharmacokinetics of immunosuppressant after organ transplantations was not identified in the present study. Further study is needed to achieve personalized pharmacotherapy with miRNAs.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2016年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26460196","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"奥田, 真弘","creatorNameLang":"ja"},{"creatorName":"OKUDA, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岩本, 卓也","creatorNameLang":"ja"},{"creatorName":"IWAMOTO, Takuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"池村, 健治","creatorNameLang":"ja"},{"creatorName":"IKEMURA, Kenji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"村木, 優一","creatorNameLang":"ja"},{"creatorName":"MURAKI, Yuichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"伊佐地, 秀司","creatorNameLang":"ja"},{"creatorName":"ISAJI, Shuji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-08"}],"displaytype":"detail","filename":"2018RP0056.pdf","filesize":[{"value":"147.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018RP0056","url":"https://mie-u.repo.nii.ac.jp/record/12438/files/2018RP0056.pdf"},"version_id":"b65cf5d0-21e8-4d45-934e-274b54ff1df3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"臓器移植","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫抑制薬","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症性サイトカイン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"生体肝移植時のカルシニューリン阻害薬の体内動態制御におけるマイクロRNAの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生体肝移植時のカルシニューリン阻害薬の体内動態制御におけるマイクロRNAの役割","subitem_title_language":"ja"},{"subitem_title":"Role of microRNA on the pharmacokinetics of calcineurin inhibitors after living liver transplantation","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684729425"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"12438","relation_version_is_last":true,"title":["生体肝移植時のカルシニューリン阻害薬の体内動態制御におけるマイクロRNAの役割"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:10:23.433219+00:00"}