{"created":"2023-06-19T11:43:04.649601+00:00","id":12470,"links":{},"metadata":{"_buckets":{"deposit":"f82995ac-0f12-4f9a-bcb9-2b02f1dcc988"},"_deposit":{"created_by":15,"id":"12470","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"12470"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012470","sets":["515:756:1692664505137"]},"author_link":["40695"],"control_number":"12470","item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017-05-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"耐糖能異常とは、インスリンの分泌不足や作用不良などによって生じる血糖値の正常化機構が不良になった状態である。耐糖能異常を早期に発見し治療介入することが、これからの予防的治療戦略として注目されている。本研究では、2型糖尿病モデルゼブラフィッシュを開発し、その網羅的遺伝子発現解析からHmox1などの治療標的遺伝子を発見した。これらの遺伝子の発現抑制により、糖尿病および耐糖能異常発症の改善が認められた。","subitem_description_type":"Abstract"},{"subitem_description":"Impaired glucose tolerance is a pre-diabetic state of type 2 diabetes mellitus (T2DM) that is associated with either insulin resistance, low insulin production or both. Early detection and therapeutic treatment of impaired glucose tolerance is now attracting attention as a prophylactic treatment strategy. In this study, we developed a T2DM model zebrafish and identified novel therapeutic targets gene (such as hmoxl) by RNA-seq analysis. Knockdown study of these genes ameliorated the T2DM phenotypes including glucose intolerance.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2015年度～2016年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15K19074","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"臧, 黎清","creatorNameLang":"ja"},{"creatorName":"ZANG, Liqing","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-05-08"}],"displaytype":"detail","filename":"2018RP0095.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2018RP0095","url":"https://mie-u.repo.nii.ac.jp/record/12470/files/2018RP0095.pdf"},"version_id":"03439558-a1eb-402c-9aed-e70a41a8ff2e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"2型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"ゼブラフィッシュ","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子抑制","subitem_subject_scheme":"Other"},{"subitem_subject":"治療標的遺伝子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"耐糖能異常ゼブラフィッシュを用いた治療標的遺伝子及び早期診断バイオマーカーの探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"耐糖能異常ゼブラフィッシュを用いた治療標的遺伝子及び早期診断バイオマーカーの探索","subitem_title_language":"ja"},{"subitem_title":"Exploration study on gene therapeutic targets and biomarkers for early diagnosis using an impaired glucose tolerance zebrafish model","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692664505137"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-05-08"},"publish_date":"2019-05-08","publish_status":"0","recid":"12470","relation_version_is_last":true,"title":["耐糖能異常ゼブラフィッシュを用いた治療標的遺伝子及び早期診断バイオマーカーの探索"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-21T04:46:29.451258+00:00"}