{"created":"2023-06-19T11:43:17.881900+00:00","id":12786,"links":{},"metadata":{"_buckets":{"deposit":"0c2d6d66-a9cf-4766-9a9f-4504f28813cc"},"_deposit":{"created_by":16,"id":"12786","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"12786"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012786","sets":["334:608:618:915"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-03-25","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-03-25"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Hypoxia-ischaemia (HI) is a major contributor to preterm brain injury, although there are currently no reliable biomarkers for identifying infants who are at risk. We tested the hypothesis that fetal heart rate (FHR) and FHR variability (FHRV) would identify evolving brain injury after HI. Fetal sheep at 0.7 of gestation were subjected to either 15 (n = 10) or 25 min (n = 17) of complete umbilical cord occlusion or sham occlusion (n = 12). FHR and four measures of FHRV [short-term variation, long-term variation, standard deviation of normal to normal R-R intervals (SDNN), root mean square of successive differences) were assessed until 72 h after HI. All measures of FHRV were suppressed for the first 3–4 h in the 15 min group and 1–2 h in the 25 min group. Measures of FHRV recovered to control levels by 4 h in the 15 min group, whereas the 25min group showed tachycardia and an increase in short-termvariation and SDNN from 4 to 6 h after occlusion. The measures of FHRV then progressively declined in the 25 min group and became profoundly suppressed from 18 to 48 h. A partial recovery of FHRV measures towards control levels was observed in the 25 min group from 49 to 72 h. These findings illustrate the complex regulation of FHRV after both mild and severe HI and suggest that the longitudinal analysis of FHR and FHRV after HI may be able to help determine the timing and severity of preterm HI.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/The Department of Obstetrics and Gynaecology, Mie University, Mie, Japan","subitem_description_type":"Other"},{"subitem_description":"12p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第1942号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1113/JP275434","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"The Journal of Physiology 2018;596(23):6093-6104に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamaguchi, Kyohei","creatorNameLang":"en"},{"creatorName":"ヤマグチ, キョウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"山口, 恭平","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-16"}],"displaytype":"detail","filename":"2018DM0326.pdf","filesize":[{"value":"761.8 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2018DM0326.pdf","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/12786/files/2018DM0326.pdf"},"version_id":"ab70de1b-5c39-4dec-9983-ea862443e968"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Evolving changes in fetal heart rate variability and brain injury after hypoxia-ischaemia in preterm fetal sheep","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evolving changes in fetal heart rate variability and brain injury after hypoxia-ischaemia in preterm fetal sheep","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["915"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-10-16"},"publish_date":"2019-10-16","publish_status":"0","recid":"12786","relation_version_is_last":true,"title":["Evolving changes in fetal heart rate variability and brain injury after hypoxia-ischaemia in preterm fetal sheep"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-10-31T06:02:16.524282+00:00"}