{"created":"2023-06-19T11:43:19.983760+00:00","id":12835,"links":{},"metadata":{"_buckets":{"deposit":"874cceda-5983-42d4-8444-b4300fbca0b4"},"_deposit":{"created_by":16,"id":"12835","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"12835"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00012835","sets":["334:608:618:1214"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-07-17","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2019-07-17"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Down and feather materials have been commonly used and promoted as natural stuffing for warm clothing and bedding. These materials tend to become more allergenic as they become contaminated with microorganisms, in addition to being subjected to several kinds of chemical treatments. The biological or chemical contaminants in these materials pose a major risk to human health, to consumers and manufacturers alike. Here, we report the development of an integrative evaluation method for down and feather materials to assess bacterial contamination and in vivo toxicity. Methods: To assess bacterial contamination, we quantified 16S ribosomal RNA, performed culture tests, and established a conversion formula. To determine in vivo toxicity, we performed a zebrafish embryo toxicity testing (ZFET). Results: Washing the material appropriately decreases the actual number of bacteria in the down and feather samples; in addition, after washing, 16S rRNA sequencing revealed that the bacterial compositions were similar to those in rinse water. The ZFET results showed that even materials with low bacterial contamination showed high toxicity or high teratogenicity, probably because of the presence of unknown chemical additives. Conclusions: We established an integrative evaluation method for down and feather safety, based on bacterial contamination with in vivo toxicity testing.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Kawada Feather Co., Ltd., Nagoya, Aichi 453-0064, Japan","subitem_description_type":"Other"},{"subitem_description":"9p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙医学第1038号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/ijms20061434","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者(ヨミ)","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"International Journal of Molecular Sciences 2019,20(6),1434に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ(三重大)","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawada, Toshikatsu","creatorNameLang":"en"},{"creatorName":"カワダ, トシカツ","creatorNameLang":"ja-Kana"},{"creatorName":"河田, 敏勝","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2019-10-24"}],"displaytype":"detail","filename":"2019DM0704.pdf","filesize":[{"value":"889.9 kB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2019DM0704.pdf","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/12835/files/2019DM0704.pdf"},"version_id":"61ae6719-5be3-41d0-8abd-10c43045b1a6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"allergy","subitem_subject_scheme":"Other"},{"subitem_subject":"microbiome","subitem_subject_scheme":"Other"},{"subitem_subject":"pollution","subitem_subject_scheme":"Other"},{"subitem_subject":"environment","subitem_subject_scheme":"Other"},{"subitem_subject":"clothes","subitem_subject_scheme":"Other"},{"subitem_subject":"bedding","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"An Integrative Evaluation Method for the Biological Safety of Down and Feather Materials","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"An Integrative Evaluation Method for the Biological Safety of Down and Feather Materials","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["1214"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2019-10-24"},"publish_date":"2019-10-24","publish_status":"0","recid":"12835","relation_version_is_last":true,"title":["An Integrative Evaluation Method for the Biological Safety of Down and Feather Materials"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-10-26T00:44:33.379612+00:00"}