{"created":"2023-06-19T11:43:37.761761+00:00","id":13242,"links":{},"metadata":{"_buckets":{"deposit":"50e9a1d0-f84e-4932-b43d-03221508c9ab"},"_deposit":{"created_by":15,"id":"13242","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13242"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013242","sets":["556:861:1692668146501"]},"author_link":["42905"],"control_number":"13242","item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は、炎症物質と嗅覚障害の新しい治療法確立を目的とし、まずは、生きたヒト嗅細胞を用いて、ホールセルパッチクランプ法による解析データを、既に多数報告されているイモリ嗅細胞のデータと比較した。そして、炎症物質の投与により、どのような影響を受けるかを確認した。また、炎症制御が外傷性嗅覚障害に対する効果もマウスを用いて検討も行った。\nその結果、ヒト嗅細胞の基礎的データを得ることが出来たが、炎症物質の影響を確認できなかった。これはヒト嗅細胞が他の動物種と比べて極めて極めて組織が脆弱であるためだろう。しかし、本研究は外傷性嗅覚障害マウスに有効な物質を複数見つけ、今後の臨床応用が期待される。","subitem_description_type":"Abstract"},{"subitem_description":"The purpose of this study was to establish new therapeutic methods for inflammatory substances in olfactory disorders. First, we analyzed data obtained by the whole-cell patch-clamp method using living human olfactory cells. As a result, we have reported many new olfactory cell findings. Subsequently, we confirmed the reactions caused by inflammatory substance administration. Inflammation control was also examined and its effects on traumatic olfactory disorder in mice.\n As a result, preliminary results on human olfactory cells were obtained, but the influence of inflammatory substances could not be confirmed. This is probably because human olfactory cells are extremely fragile compared to other animal species. However, this study discovered multiple effective substances in traumatic olfactory-impaired mice, which are expected to be applied clinically in the future.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2014年度～2017年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"26861370","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"玉利, 健悟","creatorNameLang":"ja"},{"creatorName":"タマリ, ケンゴ","creatorNameLang":"ja-Kana"},{"creatorName":"TAMARI, Kengo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"42905","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-01-21"}],"displaytype":"detail","filename":"2019RP0112.pdf","filesize":[{"value":"267.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0112","url":"https://mie-u.repo.nii.ac.jp/record/13242/files/2019RP0112.pdf"},"version_id":"2b3f8718-252d-4d12-9efd-21399b276258"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"電気生理学","subitem_subject_scheme":"Other"},{"subitem_subject":"嗅覚","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症を標的とした嗅覚障害治療法の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症を標的とした嗅覚障害治療法の確立","subitem_title_language":"ja"},{"subitem_title":"The establishment of therapeutic methods for olfactory disorders with a focus on inflammation","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692668146501"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-21"},"publish_date":"2020-01-21","publish_status":"0","recid":"13242","relation_version_is_last":true,"title":["炎症を標的とした嗅覚障害治療法の確立"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-27T00:12:42.239252+00:00"}