{"created":"2023-06-19T11:43:38.515287+00:00","id":13260,"links":{},"metadata":{"_buckets":{"deposit":"20dd39b8-16ca-43cf-84fd-ca8760ab04a2"},"_deposit":{"created_by":15,"id":"13260","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13260"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013260","sets":["334:627:1692670441288"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-18","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"我々はポリオウイルスが神経芽腫細胞に対して抗腫瘍活性を持つ事を報告してきた。研究で用いた細胞は、マウス神経芽腫細胞（N2a）にCD155を導入した細胞であるため、強制発現させたCD155が抗腫瘍免疫の標的になっている可能性がある。CD155tgA/JマウスにN2aを移植すると腫瘤形成を認めたが、抗腫瘍免疫を獲得したマウスにN2aを移植すると腫瘤形成しなかったため、CD155は抗腫瘍免疫の標的になっていない。\n抗腫瘍免疫を獲得したマウスの脾細胞と神経芽腫細胞と混合培養すると、抗腫瘍効果を認めた。CD8T細胞を除去すると抗腫瘍効果が消失したため、CD8T細胞が抗腫瘍免疫に重要である。","subitem_description_type":"Abstract"},{"subitem_description":"We have demonstrated that neuroblastoma (NB) subcutaneously implanted in immuno-competent mice is eliminated by intratumoral administration of poliovirus (PV). Our results also suggested that the in vivo destruction of NB cells by virotherapy lead to a robust antitumor immune response. Since we used CD155-transfected NB for experiments, CD155 might be a target for antitumor immune response. Although NB can grow in naïve mice, no tumor growth was observed in mice cured of NB that were reinnoculated with NB cells.\nSplenocytes harvested from NB-bearing mice treated with PV exhibited higher lytic activity against NB cells than did those from splenocytes derived from naïve mice. In vitro T-cell depletion experiments indicated that CD8+ T cells were essential for the cytotoxic antitumor activity of splenocytes.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2015年度～2017年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15K09650","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"豊田, 秀実","creatorNameLang":"ja"},{"creatorName":"トヨダ, ヒデミ","creatorNameLang":"ja-Kana"},{"creatorName":"TOYODA, HIDEMI","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-21"}],"displaytype":"detail","filename":"2019RP0027.pdf","filesize":[{"value":"239.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0027","url":"https://mie-u.repo.nii.ac.jp/record/13260/files/2019RP0027.pdf"},"version_id":"ebfb0202-164d-4c7f-be9c-2a3150740a20"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"神経芽腫","subitem_subject_scheme":"Other"},{"subitem_subject":"ポリオウイルス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ポリオウイルスを用いた神経芽腫の新しい治療法の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ポリオウイルスを用いた神経芽腫の新しい治療法の研究","subitem_title_language":"ja"},{"subitem_title":"Novel treatment for neuroblastoma by using live-attenuated poliovirus","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670441288"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-21"},"publish_date":"2020-01-21","publish_status":"0","recid":"13260","relation_version_is_last":true,"title":["ポリオウイルスを用いた神経芽腫の新しい治療法の研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:01:15.000062+00:00"}