{"created":"2023-06-19T11:43:38.765398+00:00","id":13266,"links":{},"metadata":{"_buckets":{"deposit":"7dee5f30-b5f8-4675-8b24-0220f16cc3d0"},"_deposit":{"created_by":15,"id":"13266","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13266"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013266","sets":["334:627:1692670441288"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究は、癌特異的に分泌されるGlypican-1陽性エクソソームに包埋された遺伝子情報を解析することで、非侵襲的なLiquid biopsyによる大腸癌患者の診断から治療にわたる戦略が構築可能か検証することである。今回の研究の経過の中でLiquid biopsyを臨床応用するには大腸癌特異的エクソソームを分離することが重要であることを報告した。さらに大腸癌細胞株分泌エキソソームを網羅的蛋白解析を施行し、公共データベースを用いて解析を行うと、AUC0.9以上で癌組織特異的に発現を示す蛋白群の同定に成功した。現在、それらを用いて、非侵襲的診断マーカーとしての有用性の確認作業をおこなっている。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we focused on exosome-expressed protein, including Glypican-1, to develop novel screening method using exosomal miRNAs in CRC patients. During the series of this project, we successfully find several novel findings. As first, we directly compared between exosomal and serum-derived miRNAs in adenoma patients, and showed that diagnostic potential of serum-derived miRNAs are superior to exosomal miRNAs in these patients. Second, we performed comprehensive protein profiling using exosomal protein from CRC cells and normal cells, and identified canditate proteins to specifically expressed in CRC tissues. Finally, we demonstrated that serum miR-1290 could be used as a diagnostic and prognotic biomarker in CRC patients.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2017年度科学研究費補助金(挑戦的萌芽研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K15612","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"KUSUNOKI, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"トイヤマ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"TOIYAMA, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"田中, 光司","creatorNameLang":"ja"},{"creatorName":"タナカ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"TANAKA, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"井上, 靖浩","creatorNameLang":"ja"},{"creatorName":"イノウエ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"INOUE, Yasuhiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-21"}],"displaytype":"detail","filename":"2019RP0035.pdf","filesize":[{"value":"426.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0035","url":"https://mie-u.repo.nii.ac.jp/record/13266/files/2019RP0035.pdf"},"version_id":"0558e76d-ccf6-4623-980b-15a566939c47"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"エキソソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌特異的エクソソーム包埋遺伝子情報をもとにした大腸癌診断ならびに治療戦略の確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌特異的エクソソーム包埋遺伝子情報をもとにした大腸癌診断ならびに治療戦略の確立","subitem_title_language":"ja"},{"subitem_title":"Development of novel screening method using exosomal miRNAs in CRC.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670441288"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-21"},"publish_date":"2020-01-21","publish_status":"0","recid":"13266","relation_version_is_last":true,"title":["癌特異的エクソソーム包埋遺伝子情報をもとにした大腸癌診断ならびに治療戦略の確立"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:01:29.531516+00:00"}