{"created":"2023-06-19T11:43:39.098644+00:00","id":13274,"links":{},"metadata":{"_buckets":{"deposit":"0a4cc6d7-86ae-4919-9c2c-970c0842c9cf"},"_deposit":{"created_by":15,"id":"13274","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13274"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013274","sets":["334:627:1692670441288"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-16","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"アルコール肝炎マウスモデルを使った実験により、アルコール摂取により障害を受けた肝細胞は小さな粒子を放出すること、さらにこの粒子は障害肝細胞の細胞成分を含有していることが分かった。この粒子の生物活性を調べるために、マウスの肝内マクロファージを分離し粒子を添加したところ、粒子はマクロファージに取り込まれ、さらにマクロファージが活性化（炎症に寄与）することが分かった。この結果は、障害肝細胞由来の粒子が「細胞間伝達物質」としてアルコール性肝障害の病態進行に寄与していることを意味している。将来的には、粒子成分を阻害することでマクロファージ活性を阻止する治療法の開発を行う予定である。","subitem_description_type":"Abstract"},{"subitem_description":"We revealed that damaged hepatocytes treated with alcohol released extracellular vesicles (EVs) and these EVs were contained the cellular composition from damaged hepatocytes using alcoholic liver disease mouse model. To investigate EV biological function, we isolated hepatic macrophages and incubated hapatic macrophages with EVs. EVs were internalized in the hepatic macrophages resulted in activation of hepatic macrophages. These resulted indicated that hepatocyte-derived EVs contributed the progression of alcoholic liver disease as cell-to-cell communicators. We will identify the EV composition to associate with hepatic macrophage activation and will develop new therapeutic approaches for inhibition of hepatic macrophage activation in future study.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2017年度科学研究費補助金(研究活動スタート支援)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16H06872","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"江口, 暁子","creatorNameLang":"ja"},{"creatorName":"エグチ, アキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Eguchi, Akiko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-21"}],"displaytype":"detail","filename":"2019RP0048.pdf","filesize":[{"value":"85.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0048","url":"https://mie-u.repo.nii.ac.jp/record/13274/files/2019RP0048.pdf"},"version_id":"c2c28e2c-f170-46e5-96b6-5b6ef7821980"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝臓","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞外小胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"障害肝細胞から分泌されるヘパトソームはアルコール性肝炎の病態進行に寄与する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"障害肝細胞から分泌されるヘパトソームはアルコール性肝炎の病態進行に寄与する","subitem_title_language":"ja"},{"subitem_title":"The hepatosomes released from damaged hepatocytes will contribute the progression of ALD","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692670441288"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-21"},"publish_date":"2020-01-21","publish_status":"0","recid":"13274","relation_version_is_last":true,"title":["障害肝細胞から分泌されるヘパトソームはアルコール性肝炎の病態進行に寄与する"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-09T02:01:47.832205+00:00"}