{"created":"2023-06-19T11:43:39.392840+00:00","id":13281,"links":{},"metadata":{"_buckets":{"deposit":"f71092f7-00df-4b85-ad2f-e6099d8f32b3"},"_deposit":{"created_by":15,"id":"13281","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13281"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013281","sets":["631:636:1692684750464"]},"author_link":["43232","43233","43234","43235"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-09-20","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胃癌リンパ節転移に関与するエピゲノム変化を同定することを目的に研究をおこなった。その結果miR-4286が癌進行に伴って発現増加し、リンパ節転移進展に深くかかわることが判明し、新規バイオマーカーになり得ると考えられた。DNAメチル化に関しては網羅的解析では有用なマーカーは同定しえなかったが、遺伝子発現レベルにおいて注目すると、炎症性発癌に深くかかわるとされるAngiopoietin-like protein2(ANGPTL2)が、癌組織特異的に発現増加するのみならず、病期進展に伴い発現増加し、リンパ節転移と相関するのみならず、有用な予後予測マーカーとなることを同定した。","subitem_description_type":"Abstract"},{"subitem_description":"The aim of this study was to identify clinically relevant epigenetic markers for presence of lymph node metastasis in gastric cancer. Array-based comprehensive analysis demosntrated that miR-4286 expression was significantly increased with disease development and lymph node metastasis in gastric cancer. Although we could not identify approproate candidates of methylated DNA, gene expression analysis demonstrated that increased ANGPTL2 expression was depply involved in lymph node metastasis and poor prognosis in gastric cancer patients.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2015年度～2017年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15K10094","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安田, 裕美","creatorNameLang":"ja"},{"creatorName":"ヤスダ, ヒロミ","creatorNameLang":"ja-Kana"},{"creatorName":"Yasuda, Hiromi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"トイヤマ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Toiyama, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"毛利, 靖彦","creatorNameLang":"ja"},{"creatorName":"モウリ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Mhori, Yasuhiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"Kusunoki, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"2019RP0056.pdf","filesize":[{"value":"362.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0056","url":"https://mie-u.repo.nii.ac.jp/record/13281/files/2019RP0056.pdf"},"version_id":"bc11dc9d-53d3-43f5-84d1-5379bd51d47e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胃癌","subitem_subject_scheme":"Other"},{"subitem_subject":"リンパ節転移","subitem_subject_scheme":"Other"},{"subitem_subject":"遠隔転移","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"DNAメチル化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胃癌外科的治療テーラーメード化目的のリンパ節転移同定エピゲノムパネルの確立","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃癌外科的治療テーラーメード化目的のリンパ節転移同定エピゲノムパネルの確立","subitem_title_language":"ja"},{"subitem_title":"Establishment of epigenome panel for identification of lymph node metastasis in gastric cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684750464"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"13281","relation_version_is_last":true,"title":["胃癌外科的治療テーラーメード化目的のリンパ節転移同定エピゲノムパネルの確立"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:30:07.129474+00:00"}