{"created":"2023-06-19T11:43:39.435087+00:00","id":13282,"links":{},"metadata":{"_buckets":{"deposit":"d6b1d4a5-b92b-4eec-9980-84f3cde5f0fa"},"_deposit":{"created_by":15,"id":"13282","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13282"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013282","sets":["631:636:1692684750464"]},"author_link":["43244","43245","43246","43247"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大腸癌腹膜播種進展ひいては転移進展の診断マーカーとその機序を解明するために、大腸癌腹膜播種患者の原発組織ならびに、血清microRNA の網羅的解析を行った。とくに大腸癌患者血清と健常人血清の比較において大腸癌患者血清で有意に発現上昇するmiR-1290が、癌進展にかかわるoncogenic miRNAであることを確認するとともに、組織においてのみならず血清において大腸癌患者で有意に発現上昇し、有用な早期診断・予後マーカーであった。さらに血清miR-1290は腹膜播種転移陽性患者群で有意に発現上昇をし、腹膜播種診断マーカーとして有用である可能性が示唆された。                                                                                                                                                                                                                         ","subitem_description_type":"Abstract"},{"subitem_description":"To identify miRNA biomakers for peritoneal metastasis in colorectal cancerand to clarify the funtional mechanism of these miRNAs for development of peritoneal metastasis, weperformed array-based comprehesive analysis. From this result, we demonstrated that serum miR-1290was significantly increased in CRC patients compared to healthy volunteers, and increased serummiR-1290 was significantly correlated with recurrence and poor survival in CRC. Especially, serummiR-1290 was significantly increased in CRC patients harboring peritoneal metastasis, and suggestedthat serum miR-1290 might be used as a predictive biomarker for peritoneal metastasis in CRCpatients.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2015年度～2017年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15K10134","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤川, 裕之","creatorNameLang":"ja"},{"creatorName":"フジカワ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"FUJIKAWA, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"トイヤマ, ユウジ","creatorNameLang":"ja-Kana"},{"creatorName":"TOIYAMA, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井上, 靖浩","creatorNameLang":"ja"},{"creatorName":"イノウエ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"INOUE, Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"KUSUNOKI, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"2019RP0057.pdf","filesize":[{"value":"442.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0057","url":"https://mie-u.repo.nii.ac.jp/record/13282/files/2019RP0057.pdf"},"version_id":"828d9edd-fdb5-4db4-a953-bc1c531341fa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"腹膜播種","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸癌腹膜播種に関与するmicroRNAの網羅的解析と治療戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌腹膜播種に関与するmicroRNAの網羅的解析と治療戦略","subitem_title_language":"ja"},{"subitem_title":"Comprehensive analysis of microRNAs associated with peritoneal dissemination of colorectal cancer and treatment strategy","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684750464"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"13282","relation_version_is_last":true,"title":["大腸癌腹膜播種に関与するmicroRNAの網羅的解析と治療戦略"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:30:07.288795+00:00"}