{"created":"2023-06-19T11:43:39.519249+00:00","id":13284,"links":{},"metadata":{"_buckets":{"deposit":"7facad30-6718-4020-ac0e-2aeaa03493fb"},"_deposit":{"created_by":15,"id":"13284","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13284"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013284","sets":["631:636:1692684750464"]},"author_link":["43271","43272","43273","43274","43275","43276"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"生体活性化チタン合金スクリューの表面にビスフォスフォネート（BP）製剤を吸着させた薬剤徐放型・生体活性化チタン合金スクリューの開発を行った。Ca-加熱処理を行ったTi-6Al-4V合金に10%の濃度の医療用グレードの水和ゲルを用いて1.8μmの厚みを有するコーティングを作成し、真空加熱処理を行うことによりゼラチンの溶解性を低下させた。擬似体液中でのアパタイト形成能が確認された。我々が開発したインプラントはアパタイトを形成して骨と結合し、骨吸収を抑制に働く有効濃度のミノドロン酸を徐放するため、骨粗鬆症骨での使用に有用性が高い可能性を考えた。","subitem_description_type":"Abstract"},{"subitem_description":"We have developed the bioactive Titanium (Ti)-6Al-4V alloy screw that has adrug-releasing potential of bisphosphonate. Bioacitve Ti-6Al-4V alloy were prepared by CaCl2-heattreatment. The bioactive Ti-alloy was coated by 10% hydration gel (medical use), followed by vacuumheat treatment. The surface analysis of a hydration gel-coating bioactive Ti-alloy by FE-SEM showedthat substantial \"bone-like\" hydroxy-apatite deposits covered the entire surface. This biomaterialwas shown to have the controlled-release function of Bisphosphonate with effective dose forsuppressing a bone resorption in vitro. The results of this study suggest that our newly-developedbioactive Ti alloy coated by hydration gel coating would have the possibility of effective use forthe osteoporotic bone.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2015年度～2017年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15K10402","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"明田, 浩司","creatorNameLang":"ja"},{"creatorName":"アケダ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"AKEDA, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松峯, 昭彦","creatorNameLang":"ja"},{"creatorName":"マツミネ, アキヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"MATSUMINE, Akihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"竹上, 德彦","creatorNameLang":"ja"},{"creatorName":"タケガミ, ノリヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"TAKEGAMI, Norihiko","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山口, 誠二","creatorNameLang":"ja"},{"creatorName":"ヤマグチ, セイジ","creatorNameLang":"ja-Kana"},{"creatorName":"YAMAGUCHI, Seiji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"湏藤, 啓広","creatorNameLang":"ja"},{"creatorName":"スドウ, アキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"SUDO, Akihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"山田, 淳一","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ジュンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"YAMADA, Junichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"2019RP0059.pdf","filesize":[{"value":"195.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0059","url":"https://mie-u.repo.nii.ac.jp/record/13284/files/2019RP0059.pdf"},"version_id":"268be3ab-5384-43a8-9667-9a7bc01caf78"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"生体材料","subitem_subject_scheme":"Other"},{"subitem_subject":"チタン合金","subitem_subject_scheme":"Other"},{"subitem_subject":"生体活性処理","subitem_subject_scheme":"Other"},{"subitem_subject":"薬剤溶出性材料","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"高齢化社会に適応する高機能性脊椎インプラントの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高齢化社会に適応する高機能性脊椎インプラントの開発","subitem_title_language":"ja"},{"subitem_title":"The development of high-functional spinal implant to adapt to an aging society","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684750464"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"13284","relation_version_is_last":true,"title":["高齢化社会に適応する高機能性脊椎インプラントの開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:30:12.155327+00:00"}