{"created":"2023-06-19T11:43:39.560802+00:00","id":13285,"links":{},"metadata":{"_buckets":{"deposit":"7aeafad3-7e18-47ba-a575-4d52ec3d3eaf"},"_deposit":{"created_by":15,"id":"13285","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13285"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013285","sets":["631:636:1692684750464"]},"author_link":["43289","43290","43291","43292"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-14","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"小児潰瘍性大腸炎の腸管粘膜標本から蛋白を抽出しプロテオミクスの手法を用いて、診断や重症度に関連するバイオマーカーの検索を行った。しかし、粘膜からの蛋白の抽出量が不十分であり有効性が認められなかった。そこで加齢に関連するmicroRNAのmethylationを測定し、miR-124とmiR-137のmethylation levelが年齢と罹病期間と相関し、colitic cancerのバイオマーカーになりうることを明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"Protein was extracted from intestinal mucosa specimens of pediatriculcerative colitis, and biomarkers related to diagnosis and severity were searched using proteomics.However, the amount of protein extracted from the mucosa was insufficient and no effectiveness wasfound. Therefore, we measured the methylation of age-related microRNA and clarified that themethylation level of miR-124 and miR-137 correlates with age and duration of disease and it can be abiomarker of colitic cancer.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2015年度～2017年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"15K10920","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内田, 恵一","creatorNameLang":"ja"},{"creatorName":"ウチダ, ケイイチ","creatorNameLang":"ja-Kana"},{"creatorName":"UCHIDA, Keiichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"井上, 幹大","creatorNameLang":"ja"},{"creatorName":"イノウエ, ミキヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"INOUE, Mikihiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"大竹, 耕平","creatorNameLang":"ja"},{"creatorName":"オオタケ, コウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"OTAKE, Kohei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"クスノキ, マサト","creatorNameLang":"ja-Kana"},{"creatorName":"KUSUNOKI, Masato","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"2019RP0061.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0061","url":"https://mie-u.repo.nii.ac.jp/record/13285/files/2019RP0061.pdf"},"version_id":"cc1330e5-bad1-4bf8-86e0-7ece87199a07"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"潰瘍性大腸炎","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"プロテオミクスを用いた小児炎症性腸疾患の新規マーカーの探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"プロテオミクスを用いた小児炎症性腸疾患の新規マーカーの探索","subitem_title_language":"ja"},{"subitem_title":"New biomarkers of pediatric inflammatory bowel disease using proteomics","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684750464"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"13285","relation_version_is_last":true,"title":["プロテオミクスを用いた小児炎症性腸疾患の新規マーカーの探索"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:30:15.400512+00:00"}