{"created":"2023-06-19T11:43:39.773790+00:00","id":13290,"links":{},"metadata":{"_buckets":{"deposit":"803ec398-8065-47c3-b398-c341b2be34e3"},"_deposit":{"created_by":15,"id":"13290","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13290"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013290","sets":["631:636:1692684750464"]},"author_link":["43334"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-15","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"PD後に発症する脂肪肝炎の病態を マウスもしくはラットPDモデルを作成し、その原因をMMP-9 に着目し、解明するため本研究を行った。マウスPD後、HE染色で肝細胞の空洞化がみられ脂肪沈着が示唆された。しかし、マウスにPDを施行すると術後から極度の食欲不振に陥り脱水状態となり24h以上の生存が得られないためRatを用いたPDモデルを作成することとした。ラットにおいてもPD群でTNF-aのmRNA発現上昇を認めMMP-9の免疫染色でもPDモデルで肝MMP-9発現上昇を認めた。HE染色では肝細胞の空洞化、脂肪沈着が認められたがラットでも術後極度の食欲不振を認め48h以上の生存が困難であった。","subitem_description_type":"Abstract"},{"subitem_description":"We performed the study to prove the etiology of development of NASH after a pancreaticoduodenectomy (PD) using mice or rat PD models. Even in mice and rat PD model, significant liver injury and fat deposition to the liver parenchyma and sinusoidal injury as evidenced byPECAM-1 depression were seen at the 24 hours after PD. Nevertheless, we observed the phenomenon that mice and rat markedly lost their appetite, resulting in death. However, In rat PD model, the level of TNF-a mRNA, neutrophil infiltration and monocytes infiltration in liver are significantly potentiated, with compared to the SHAM model. In conclusion, MMP-9 upregulation might be associated with the development of NAFLD after PD.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2017年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K19917","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加藤, 宏之","creatorNameLang":"ja"},{"creatorName":"カトウ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"2019RP0066.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0066","url":"https://mie-u.repo.nii.ac.jp/record/13290/files/2019RP0066.pdf"},"version_id":"2d3ac3fb-fe7c-47d1-9217-8aacb74362bf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"膵頭十二指腸切除","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞外マトリックス","subitem_subject_scheme":"Other"},{"subitem_subject":"NAFLD","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞外マトリックスに着目した膵切除後NASH発生機序に関する分子基盤的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞外マトリックスに着目した膵切除後NASH発生機序に関する分子基盤的研究","subitem_title_language":"ja"},{"subitem_title":"Molecular basis study for revealing the pathogenesis of NAFLD after pancreatic resection focusing on extracellular matrix","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684750464"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"13290","relation_version_is_last":true,"title":["細胞外マトリックスに着目した膵切除後NASH発生機序に関する分子基盤的研究"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:30:25.321886+00:00"}