{"created":"2023-06-19T11:43:39.816462+00:00","id":13291,"links":{},"metadata":{"_buckets":{"deposit":"d066af2f-853c-4a98-bc65-96f538c7de36"},"_deposit":{"created_by":15,"id":"13291","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13291"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013291","sets":["631:636:1692684750464"]},"author_link":["43337"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-28","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"敗血症では炎症と凝固のクロストーク、いわゆる免疫反応による凝固障害（Immunothrombosis）が注目されている。これらは細菌の体内での広がりを抑制するための生体反応と考えられているが、その生成過程で血管内皮と白血球がどのように相互作用しているか不明な点が多い。我々はImmunothrombosisの病態解明のためにTMの炎症時と非炎症時の発現量をフローサイトメトリーと免疫染色により確認し、さらに白血球と血管内皮細胞との結合実験系を確立した。","subitem_description_type":"Abstract"},{"subitem_description":"Immunothrombosis, the immune response of blood vessels caused by preventing the spread of bactearia, plays an important role in inflammation and coagulation for sepsis. Many researchers are going to investigate that coagulation factor, like APC and EPCR, binds to leukocyte, leading to immunothrombosis.　We have indicated that leukocyte LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin (TM). In fact, integrin-TM interactions might be involved in the dynamic regulation of leukocyte adhesion with endothelial cells, or immunothrombosis. Based on the results, we indicated here how the coagulation factor, TM on endothelial cell, is associated with leukocyte binding. First, we confirmed that the TNF -alpha induced inflammatory response downregulates TM expression on endothelial cells. Moreover we showed that pheripheral blood mononuclear cells (PBMCs) bind to human umbilical vein endothelial cell(HUVEC) dependent upon integrin activation.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2016年度～2017年度科学研究費補助金(若手研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"16K20386","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川本, 英嗣","creatorNameLang":"ja"},{"creatorName":"カワモト, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"KAWAMOTO, Eiji","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"2019RP0069.pdf","filesize":[{"value":"250.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0069","url":"https://mie-u.repo.nii.ac.jp/record/13291/files/2019RP0069.pdf"},"version_id":"911d7615-0e1b-4fb6-af42-066cbfa655c5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"beta2 integrin","subitem_subject_scheme":"Other"},{"subitem_subject":"thrombomodulin","subitem_subject_scheme":"Other"},{"subitem_subject":"anti inflammation","subitem_subject_scheme":"Other"},{"subitem_subject":"anti coagulation","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症と凝固のクロストーク","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunothrombosis","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"β2インテグリンとトロンボモジュリンの結合が炎症と凝固に与える影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"β2インテグリンとトロンボモジュリンの結合が炎症と凝固に与える影響","subitem_title_language":"ja"},{"subitem_title":"Interaction between beta2 integrin and thrombomodulin effect to immunothrombosis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684750464"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"13291","relation_version_is_last":true,"title":["β2インテグリンとトロンボモジュリンの結合が炎症と凝固に与える影響"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:30:29.462027+00:00"}