{"created":"2023-06-19T11:43:39.858870+00:00","id":13292,"links":{},"metadata":{"_buckets":{"deposit":"640c99c4-c646-4979-bb9b-0e5dc8486ee5"},"_deposit":{"created_by":15,"id":"13292","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"13292"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:00013292","sets":["631:636:1692684750464"]},"author_link":["43340","43341","43342","43343","43344"],"item_8_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-06-15","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"変化関連脳活動は脳波や脳磁図で明瞭に記録することができ、基本的かつ重要な脳内情報処理過程を反映するものである。本研究では変化関連脳活動を用いてうつ病の神経基盤の解明を目指し、以下のことを明らかにした。(1)変化関連脳活動は不安・抑うつの性格特性と関連がある。(2) BDNF遺伝子多型において、Met キャリア健常者ではVal/Val型健常者と比較してOFF反応の振幅が高かった。(3) うつ病患者では、健常者と比較して変化関連脳活動強度は強かった。これらの結果から過剰な変化検出がうつ病の素因のひとつに挙げられるのではないかと考える。","subitem_description_type":"Abstract"},{"subitem_description":"The change-related cerebral response, an auditory evoked potential measured by electroencephalography (EEG) or magnetoencephalography (MEG), is speculated to reflect the neural processing of sensory changes, which is essential for survival. Here we investigated the neural basis of depression by using the change-related cerebral response. We obtained the following findings. (1) The change-related response might be affected by personality traits, particularly anxiety- or depression-related traits. (2) The healthy subjects with Met carrier showed significantly higher amplitudes of the off-response compared to subjects with Val/Val in the BDNF polymorphisms. (3) The amplitude of the change-related response was significantly higher in the depressive patients compared to the healthy controls. These results suggest that high sensitivity of the change detection system might be a feature of predisposition to depression.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2013年度～2017年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"25461763","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"元村, 英史","creatorNameLang":"ja"},{"creatorName":"モトムラ, エイシ","creatorNameLang":"ja-Kana"},{"creatorName":"MOTOMURA, Eishi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"前田, 正幸","creatorNameLang":"ja"},{"creatorName":"マエダ, マサユキ","creatorNameLang":"ja-Kana"},{"creatorName":"MAEDA, Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"乾, 幸二","creatorNameLang":"ja"},{"creatorName":"イヌイ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"INUI, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"谷井, 久志","creatorNameLang":"ja"},{"creatorName":"タニイ, ヒサシ","creatorNameLang":"ja-Kana"},{"creatorName":"TANII, Hisashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"城山, 隆","creatorNameLang":"ja"},{"creatorName":"シロヤマ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"SHIROYAMA, Takashi","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-01-22"}],"displaytype":"detail","filename":"2019RP0070.pdf","filesize":[{"value":"525.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"2019RP0070","url":"https://mie-u.repo.nii.ac.jp/record/13292/files/2019RP0070.pdf"},"version_id":"c3d5d2a4-37ea-452d-a2da-96a832d7e1e5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"うつ病","subitem_subject_scheme":"Other"},{"subitem_subject":"誘発電位","subitem_subject_scheme":"Other"},{"subitem_subject":"誘発磁場","subitem_subject_scheme":"Other"},{"subitem_subject":"変化関連脳活動","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"聴覚変化検出からみたうつ病の神経基盤","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"聴覚変化検出からみたうつ病の神経基盤","subitem_title_language":"ja"},{"subitem_title":"The neural basis of depression based on the auditory change detection","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1692684750464"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2020-01-22"},"publish_date":"2020-01-22","publish_status":"0","recid":"13292","relation_version_is_last":true,"title":["聴覚変化検出からみたうつ病の神経基盤"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-11-14T00:30:29.890498+00:00"}